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Projects

4 projects (0,075s)

Project

The role of interactions of adaptor protein PSTPIP2 in the development of autoinflammatory disease (GA19-05076S)

Mouse strains, in which deficiency in adaptor protein PSTPIP2 results inflammatory cytokine IL-1 beta by neutrophils. PSTPIP2 likely suppresses pathological phosphatases, SHIP1 a Csk. The mechanism of how PSTPIP2-bound mole...

Biochemistry and molecular biology

  • 2019 - 2023
  • 8 121 tis. Kč
  • 7 593 tis. Kč
  • GA ČR
Project

Molecular mechanisms of the regulation of inflammatory responses by adaptor protein PSTPIP2 (GA17-07155S)

chronic multifocal osteomyelitis, caused by the absence of adaptor protein PSTPIP2 playing dominant role in its development. PSTPIP2 likely suppresses inflammation via. Our major aim is elucidation of the molecular mechanisms of ho...

EC - Imunologie

  • 2017 - 2021
  • 6 978 tis. Kč
  • 5 991 tis. Kč
  • GA ČR
Project

Adaptor protein PSTPIP2 and chronic multifocal osteomyelitis in mouse models and human patients (GA23-06676S)

Pstpip2cmo, which due to the loss of PSTPIP2 protein suffers from neutrophil-dependent and monocytes from Pstpip2cmo mice and compare these with pathways of PSTPIP2 deficient......

Biochemistry and molecular biology

  • 2023 - 2025
  • 9 235 tis. Kč
  • 9 043 tis. Kč
  • GA ČR
Project

Function of Csk-anchoring proteins SCIMP and PSTPIP2 in leukocyte signaling and inflammation (GAP302/12/1712)

, SCIMP and PSTPIP2, involved in MHCII and M-CSF signaling, respectively. PSTPIP2...

EC - Imunologie

  • 2012 - 2017
  • 10 212 tis. Kč
  • 10 212 tis. Kč
  • GA ČR
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