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10 018 (0,155s) •

Project

Nové koncepty a nástroje pro racionální design enzymů (LH14027)

proteins with modified access routes and gates. Designed proteins, and the software tool for design of tunnels and gates in proteins.. The concept of linking the de novo design of active site wit...

CE - Biochemie

  • 2014 - 2016
    • •
  • 1 943 tis. Kč
    • •
  • 1 943 tis. Kč
    • •
  • MŠMT
Project

Isolation of high quality protein for animal feed through a technology of complex processing of chrome shavings and similar feedstock (TM03000062)

1. Development and design of the technological process for wet-blue leather waste treatment to recover protein for animal feed production 2. Verification of key processes at pilot scale 3. Preparation of isolated protein sa...

Chemical engineering (plants, products)

  • 2022 - 2025
    • •
  • 9 645 tis. Kč
    • •
  • 7 015 tis. Kč
    • •
  • TA ČR
Project

New tools of label-free electrochemical analysis of protein interactions with nucleic acids and proteins (GA18-18154S)

that can contribute by new insights about complex protein systems. We wish to take advantage of electrochemical approaches to design new tools for the analysis of protein in the Applicant laboratory, showing that particula...

Biophysics

  • 2018 - 2021
    • •
  • 3 613 tis. Kč
    • •
  • 3 433 tis. Kč
    • •
  • GA ČR
Project

Multidisciplinary Approach to Drug Design - Inhibition of Carbohydrate Acting Proteins (LH13055)

to design glycomimetics based inhibitors. Selected lectins and glycosyltransferase connected with infection and cancer diseases will be used as model proteins, which and will be composed of searching for carbohydrate-binding pr...

CE - Biochemie

  • 2013 - 2015
    • •
  • 1 379 tis. Kč
    • •
  • 1 379 tis. Kč
    • •
  • MŠMT
Project

SubTHz metamaterial microfluidic chips with strong interaction with protein nanomachines (EH22_010/0008936)

The TeraProChips project brings technologies to amplify the interaction of proteins with electromagnetic fields using subterahertz (subTHz) metamaterials polaritons with field enhancement and the design of topological photonic cryst...

Health-related biotechnology

  • 2025 - 2027
    • •
  • 3 904 tis. Kč
    • •
  • 988 tis. Kč
    • •
  • MŠMT
Project

Rational re-design of microbial enzymes involved in degradation of toxic organic pollutants. (ME 276)

. The impact of the changes in proteins structure on activity and specificity will be tested using steady-state kinetic measurements. Design of the mutant proteins will be conducted using computer modelling. Mutant prot...

EB - Genetika a molekulární biologie

  • 1998 - 2002
    • •
  • 3 260 tis. Kč
    • •
  • 1 160 tis. Kč
    • •
  • MŠMT
Project

Bioconjugation reactions for cross-linking of proteins to DNA (GA18-03305S)

We plan to develop new bioconjugation reactions for specific cross-linking of proteins to DNA. We will design and synthesize novel nucleotides and nucleoside and we will study the cross-link reactions with proteins which sp...

Organic chemistry

  • 2018 - 2022
    • •
  • 6 012 tis. Kč
    • •
  • 5 301 tis. Kč
    • •
  • GA ČR
Project

InterBioMed (LO1302)

The aim of the project is to study mechanism of interactions between pathogens and their hosts, to investigate regulation of cancer development, and to design and develop new types of drugs targeting these mechanisms.......

CE - Biochemie

  • 2014 - 2019
    • •
  • 233 180 tis. Kč
    • •
  • 116 590 tis. Kč
    • •
  • MŠMT
Project

Monitoring protein-protein interactions in vivo (IAA500960802)

Nearly all biochemical, physiological and regulatory processes depend on protein-protein interactions. Their dynamics and strength is crucial and even subtle is to develop strategies for monitoring protein-protein ...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 4 084 tis. Kč
    • •
  • 4 084 tis. Kč
    • •
  • AV ČR
Project

Structural study of protein p12 from Mason-Pfizer monkey virus using NMR spectroscopy (GP203/02/P098)

be utilized for a design of suitable inhibitor or viral capsid assembly. The protein is cleaved by protease yielding six proteins: p10 (matrix protein - MA), pp24/18, p12, p27 (capsid protein - CA), p14 (...

CE - Biochemie

  • 2002 - 2004
    • •
  • 359 tis. Kč
    • •
  • 209 tis. Kč
    • •
  • GA ČR
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