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1 931 (0,097s) •

Project

Atherosclerotic changes and DNA adducts (NM10)

Determination of DNA adducts in the thoracic aorta of sudden died men, aged 40 -60 years, as preclinical biomarkers of atherosclerotic changes.......

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 803 tis. Kč
    • •
  • 2 797 tis. Kč
    • •
  • MZ
Project

Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs. (NL6058)

: Recognitionof platinum-DNA adducts by human nucleotide excision repair (NER) depends,it is necessary to obtain platinum-DNA adducts that distort the double helix without eliciting of DNA substrates conta...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • MZ
Project

New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens (2B08051)

biomarkers of the DNA damage by xenobiotics and on the development of analytical methods to detect and quantitate specific DNA adducts in urine. Adenine and guanine DNA adducts for their determination in ...

CB - Analytická chemie, separace

  • 2008 - 2011
    • •
  • 21 715 tis. Kč
    • •
  • 19 426 tis. Kč
    • •
  • MŠMT
Project

Recruitment of protective mechanisms against brain hypoxia by natural agents (GA305/99/0976)

the mostcommon tumore. An important aspect of this approach is to find the DNA adduct the effect of DNA topology on binding modes of new anticancer Pt and Ru complexes to DNA and complex theoretical backg...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 972 tis. Kč
    • •
  • 972 tis. Kč
    • •
  • GA ČR
Project

Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein (IAA401990701)

of patients' treatment could be developed. The binding of platinum cytostatics to ds-DNA sensitive and rapid detection of DNA and metallothionein will be optimised.......

CG - Elektrochemie

  • 2007 - 2011
    • •
  • 2 904 tis. Kč
    • •
  • 2 904 tis. Kč
    • •
  • AV ČR
Project

Study on mechanism of antineoplastic action of an anticancer drug ellipticine (GA203/06/0329)

are formed also in DNA of target tumor tissues and whether the adduct formation correlatewith pharmacological effects. Another question is whether DNA adducts of healthy be identified. From the point of view of th...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 190 tis. Kč
    • •
  • 1 190 tis. Kč
    • •
  • GA ČR
Project

N7 Substituted guanines for early diagnostics of DNA damage; development of synthetic and analytical methods (GA203/06/0888)

Electrophilic xenobiotics are capable of binding to nucleobases in DNA forming DNA adducts. This may lead to mutations and initiate the process of carcinogenesis-Hydroxyalkylguanines and 7-hydroxyalkenylguanines, DNA

CC - Organická chemie

  • 2006 - 2008
    • •
  • 1 403 tis. Kč
    • •
  • 1 403 tis. Kč
    • •
  • GA ČR
Project

DNA Adducts determination among the persons occupationally and environmentally exposed to alkenes. (IZ3157)

FM - Hygiena

  • 1995 - 1997
    • •
  • 966 tis. Kč
    • •
  • 966 tis. Kč
    • •
  • MZ
Project

DNA interactions of polynuclear platinum (ME 152)

of DNA. Specific goals of this project are to prepare specific adducts of dinuclear investigate these adducts from the viewpoint of consequences of their formation for DNA on a hypothesis that a change of their

FR - Farmakologie a lékárnická chemie

  • 1998 - 2000
    • •
  • 5 344 tis. Kč
    • •
  • 2 127 tis. Kč
    • •
  • MŠMT
Project

Characterisation of covalent adducts of relevant industrial xenobiotics with human globin (GA303/00/0923)

with biological macromolecules ( proteins, DNA) covalent adducts, which may cause adverse a number of procedures for determination of specific adducts with blood proteins in protein primary structure, adduct stech...

CE - Biochemie

  • 2000 - 2002
    • •
  • 4 770 tis. Kč
    • •
  • 1 744 tis. Kč
    • •
  • GA ČR
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