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11 (0,094s) •

Project

Preventing motor deficits after resective epilepsy surgery in children (NV15-30456A)

Epilepsy surgery represents the only hope for children with focal intractable epilepsy. The main goal of our project is to improve surgical outcomes and quality of life in children undergoing epilepsy surgery in proximity to the primary motor cortex ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2018
    • •
  • 6 191 tis. Kč
    • •
  • 6 191 tis. Kč
    • •
  • MZ
Project

Analysis of patterns of abnormal leukocyte signaling in childhood diseases using mass cytometry and machine learning. (NU23-07-00170)

The project aims to detect abnormalities in intracellular signaling in patients with inborn errors of hematopoiesis, which manifest as a wide range of symptoms in childhood. We propose to study leukocyte responses to a battery of stimuli via measurem...

Paediatrics

  • 2023 - 2026
    • •
  • 15 611 tis. Kč
    • •
  • 15 611 tis. Kč
    • •
  • MZ
Project

Life-course de-standardization in the contemporary Czech Republic (GA403/09/0038)

We propose to employ qualitative and quantitative methodology to investigate the de-standardization of the life course in the Czech Republic. We propose to study both its behavioral and normative aspects. The quantitative part of the project would re...

AO - Sociologie, demografie

  • 2009 - 2011
    • •
  • 2 694 tis. Kč
    • •
  • 2 694 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular-genetic characterization of selected hereditary defects of erythropoiesis (NV19-07-00412)

This project aims to establish genetic background, etiology and pathogenesis of new cases of thalassemias, enzymopathies, erythrocyte membrane defects associated with hemolytic anemia, congenital dyserythropoietic anemia as well as some congenital de...

Hematology

  • 2019 - 2023
    • •
  • 14 136 tis. Kč
    • •
  • 14 046 tis. Kč
    • •
  • MZ
Project

Mechanism of ergosterol - plant cell interaction (GP203/09/P248)

Lipid substances are responsible for many signal mechanisms in plants. They play the role of hormones (brassinosteroids) or signal molecules (ergosterol). Ergosterol, the main sterol of  the fungi cytoplasmatic membrane, is one of the lipids which ac...

CE - Biochemie

  • 2009 - 2011
    • •
  • 1 305 tis. Kč
    • •
  • 1 305 tis. Kč
    • •
  • GA ČR
Project

ERK pathway activation as a prognostic tool and a prospective therapeutic target in head and neck squamous cell carcinoma and malignant melanoma (NV16-29032A)

Hyperactivation of the extracellular signal-regulated kinases (ERK) signaling pathway due to B-Raf mutations is central to melanoma development and progression. Our preliminary data suggest that aberrant ERK pathway activation, although mediated by d...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 147 tis. Kč
    • •
  • 12 147 tis. Kč
    • •
  • MZ
Project

Clinical and neurobiological predictors of response to ketamine towards personalized treatment of depression (NV18-04-00260)

Depression is a debilitating disease with high lifetime prevalence. Despite the variety of available treatment options, three major problems remain unsolved: 1) the time lag before the onset of the effect of antidepressants, 2) the treatment resistan...

Psychiatry

  • 2018 - 2022
    • •
  • 10 048 tis. Kč
    • •
  • 10 048 tis. Kč
    • •
  • MZ
Project

Central and peripheral modulation of vascular tone and sodium excretion the role of brain and kidney in pathophysiology of hypertension (NV15-25396A)

Brain and kidney play essential role in the pathogenesis of hypertension. Sympathetic nervous system (SNS) is a principle effector in the brain regulation of vascular tone and is also responsible for abnormal renal function in salt-sensitive hyperten...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2019
    • •
  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • MZ
Project

Prognostic value of epidermal growth factor receptor signalling in head and neck squamous cell carcinoma (NU23-03-00557)

The elevated expression of epidermal growth factor receptor (EGFR) is considered as an important factor in the development and progression of squamous cell carcinomas of the head and neck (HNSCC). EGFR-targeting by cetuximab in combination with other...

Oncology

  • 2023 - 2026
    • •
  • 11 890 tis. Kč
    • •
  • 11 890 tis. Kč
    • •
  • MZ
Project

Development of novel activators of mTOR signaling pathway as adjunct therapy in treatment-resistant depression (NW24-04-00422)

Depression is a mental state of low mood and aversion to activity. Furthermore, numerous studies provide evidence of a significant correlation between depression and disturbances in the circadian rhythm. Depression that does not achieve clinically re...

Pharmacology and pharmacy

  • 2024 - 2027
    • •
  • 13 292 tis. Kč
    • •
  • 13 292 tis. Kč
    • •
  • MZ
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