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17 (0,103s) •

Project

Yeast - model organism to study lipid rafts and their potential functions (GA204/06/0009)

. These microdomains are called rafts, and they have been suggested to play a role in a wide range to unambiguously visualize rafts within the membranes of living cells.The meanswe have elaborated so far (localization of raft

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 369 tis. Kč
    • •
  • 1 369 tis. Kč
    • •
  • GA ČR
Project

Signaling and adaptor proteins of leukocyte membrane microdomains (GEMEM/09/E011)

associated with various types of lipid rafts in leukocytes (based on preliminary results proteins responsible for their association with various types of lipid rafts in plasma domain). 3)     Biochemical and in situ characterizatio...

EC - Imunologie

  • 2009 - 2012
    • •
  • 6 633 tis. Kč
    • •
  • 6 633 tis. Kč
    • •
  • GA ČR
Project

Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts (GA310/09/2084)

Lipid raft-based, plasma membrane compartmentalization processes are essential for spatial and temporal regulation of signaling events in T cells. T cell signaling leads to early and sequential activation of Src-family tyrosine kinases Lck a...

EC - Imunologie

  • 2009 - 2014
    • •
  • 6 750 tis. Kč
    • •
  • 6 750 tis. Kč
    • •
  • GA ČR
Project

Biochemical studies of membrane rafts and immunoreceptors based on cell membrane-disintegrating copolymers (GA19-04047S)

Biochemical studies on cell membrane microdomains (especially membrane rafts) and membrane receptor complexes have been based on membrane disintegration by detergents, yielding detergent resistant membrane fragments (DRMs). However, the use ...

Polymer science

  • 2019 - 2023
    • •
  • 7 933 tis. Kč
    • •
  • 7 648 tis. Kč
    • •
  • GA ČR
Project

Biodegradable high-molecular-weight HPMA copolymers prepared by controlled radical RAFT polymerisation (GPP207/11/P551)

RAFT polymerisation will facilitate their synthesis and ensure their narrow...

CD - Makromolekulární chemie

  • 2011 - 2014
    • •
  • 1 920 tis. Kč
    • •
  • 1 920 tis. Kč
    • •
  • GA ČR
Project

The regulatory role of NTAL in receptor-mediated signaling in mast cells (GA301/06/0361)

and associated proteins in cells activated via lipid raft components, (3) the role of NTAL microscopy on membrane sheets we will also analyze topography of NTAL and lipid raft......

EC - Imunologie

  • 2006 - 2008
    • •
  • 4 831 tis. Kč
    • •
  • 4 831 tis. Kč
    • •
  • GA ČR
Project

Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells (MEB040703)

A number of studies, including our own preliminary data, have shown that TRAIL (an important member of the TNF family) works synergistically with some anticancer drugs to kill most types of tumor cells and reversed resistance to such drugs. These fin...

ED - Fyziologie

  • 2008 - 2008
    • •
  • 56 tis. Kč
    • •
  • 56 tis. Kč
    • •
  • MŠMT
Project

Advanced polymers for anti-biofouling surfaces (7AMB13FR021)

The main goal of this project is the synthesis of novel and well-defined low-fouling coatings that are highly resistant the attachment of biomolecules via modern controlled RAFT polymerization. Physicochemical properties of prepared polymers...

CD - Makromolekulární chemie

  • 2013 - 2014
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
Project

Influence of hormones on sucking of blood by autogenous and anautogenous females of Culex pipiens complex (GA206/97/0324)

of mating on formation of autogenous egg raft in Culex molestus and physiological...

EA - Morfologické obory a cytologie

  • 1997 - 1999
    • •
  • 1 921 tis. Kč
    • •
  • 1 049 tis. Kč
    • •
  • GA ČR
Project

Membrane interactions of proteins associated with alzheimer's disease and parkinson's disease implications for diseases' pathologies and therapeutic avenues (LH13259)

Aberrant misfolding and aggregation of amyloidogenic proteins is implicated in the progression of neurodegenerative diseases, including Alzheimer?s disease, Parkinson?s disease, and others. While the exact molecular factors responsible for the occurr...

BO - Biofyzika

  • 2013 - 2015
    • •
  • 1 365 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • MŠMT
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