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10 (0,139s)

Project

Myb, Fos, Jun and retinoid receptor protein interactions in anti-leukemic processes (GA312/98/0679)

activities of varios retinoids in leukemic cells, on the effects of Myb, RAR and RXR...

EB - Genetika a molekulární biologie

  • 1998 - 2000
  • 1 654 tis. Kč
  • 1 572 tis. Kč
  • GA ČR
Project

In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants (GP525/05/P160)

Project proposes development and validation of a system of in vitro tests for detection of endocrine disruption potential of environmental contaminants that is unique in the Czech Republic. The tests will enable to study interactions of xenobiotics w...

DN - Vliv životního prostředí na zdraví

  • 2005 - 2007
  • 702 tis. Kč
  • 702 tis. Kč
  • GA ČR
Project

Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach (GA301/03/1055)

be significantly affected by ectopic expression of certain genes (RAR ?, RXR ?, c-myb, v-jun, c...

EB - Genetika a molekulární biologie

  • 2003 - 2005
  • 3 327 tis. Kč
  • 3 327 tis. Kč
  • GA ČR
Project

Generation of high throughput in vitro models based on reporter gene assays for toxicological and environmental application (GA16-07544S)

(PPARs) and their heterodimeric partner retinoid X receptor alpha (RXR-alpha and detection of EDCs targeting PPAR-alpha, PPAR-gamma and RXR-alpha.......

DN - Vliv životního prostředí na zdraví

  • 2016 - 2018
  • 4 691 tis. Kč
  • 4 691 tis. Kč
  • GA ČR
Project

Oxidative damage of DNA in bone marrow cells of patients with myelodysplastic syndrome - subtype refractory anemia with or without ring sideroblasts. (NR8265)

Assessment of non-specific oxidative damage of DNA in cells of glycophorine A+ and A- fraction of bone marrow from patients with RA and RARS using alkaline version of comet assay combined with application of specific restriction enzymes. Ass...

FD - Onkologie a hematologie

  • 2005 - 2008
  • 3 477 tis. Kč
  • 3 440 tis. Kč
  • MZ
Project

Research of construction-technical requirements for the use of TEN-T ground infrastructure to solve large-scale crisis situations (CK03000182)

The project aim is the research of construction-technical requirements (CTR) for the use of TEN-T to solve large-scale crisis situations (CS). For this purpose, CS resulting in extensive use of the road and railway (RaR) network will be anal...

Transport engineering

  • 2022 - 2025
  • 12 820 tis. Kč
  • 10 231 tis. Kč
  • TA ČR
Project

The significance of mitochondriál DNA mutations in the pathogenesis of refractory anaemia with ring sideroblasts (NC6001)

sideroblasts in other types MDS resp.acute leukemia 3.relationship RARS and tumours....

FD - Onkologie a hematologie

  • 2000 - 2002
  • 2 015 tis. Kč
  • 2 015 tis. Kč
  • MZ
Project

Immunohistochemical detection of predictive factors of response to interferon therapy in patients with chronic hepatitis C (NR7814)

and to process of inhibion of fibrogenesis (RXR, PPAR alpha, TGF beta 1, NF-kB, APO2, etc...

EB - Genetika a molekulární biologie

  • 2004 - 2006
  • 1 733 tis. Kč
  • 1 618 tis. Kč
  • MZ
Project

Nuclear hormone receptors conserved during evolution of Metazoa (GA304/00/1128)

of jellyfish). Onof them (named jRXR) is a homologue of vertebrate RXR. In the proposed...

EA - Morfologické obory a cytologie

  • 2000 - 2002
  • 3 821 tis. Kč
  • 3 821 tis. Kč
  • GA ČR
Project

DHFR- and non-DHFR-mediated effects of methotrexate on cellular level a study on cell lines derived from pediatric solid tumors (NT14327)

) inhibition of DNA methylation (detection of changes in methylation of genes of the RAR...

FG - Pediatrie

  • 2013 - 2015
  • 5 195 tis. Kč
  • 5 195 tis. Kč
  • MZ
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