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1 297 (0,126s) •

Project

ADAR2-mediated RNA editing in the suprachiasmatic nucleus; focus on AMPA receptors (GA19-17037S)

RNA editing refers to posttranscriptional modifications of RNA, which for excitatory transmission. Previously, we demonstrated the regulation of RNA editing upon the degree of RNA editing...

Neurosciences (including psychophysiology)

  • 2019 - 2023
    • •
  • 6 041 tis. Kč
    • •
  • 6 041 tis. Kč
    • •
  • GA ČR
Project

Structure characterization of g-RNA from Trypanosoma brucei (1K04011)

for recruitment of g-RNA into editing process.The overall objective of this work is to provide a molecularbasis for understanding g-RNA function in editing process and provide a rationalIn this grant application w...

BO - Biofyzika

  • 2004 - 2006
    • •
  • 2 507 tis. Kč
    • •
  • 1 843 tis. Kč
    • •
  • MŠMT
Project

Mitochondrial genome-wide studies of RNA-binding proteins in trypanosomes (GA15-21974S)

. Their shared unique feature is mitochondrial (mt) RNA editing, by which mRNAs are post-transcriptionally altered. RNA editing is absent from vertebrates and hence a suitable drug target. While most proteins parti...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 5 529 tis. Kč
    • •
  • 5 529 tis. Kč
    • •
  • GA ČR
Project

The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing. (IAA500960705)

The RNA metabolism of trypanosomatids has many unusual aspects, e.g U-insertion/deletion RNA editing. Much research has focused on the core RNA editing machinery. Preliminary data suggest a role in RNA...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 911 tis. Kč
    • •
  • 4 911 tis. Kč
    • •
  • AV ČR
Project

Functional analysis of candidate components of the RNA editing machinery in the flagellate Trypanosoma brucei (IAA5022302)

. In the mitochondrion of this primitive flagellate, mRNAs undergo extensive editing. Several, and thus represent promising pharmacological targets. We want to prepare, using RNA interference, inducible knock-out cells lines for gui...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 2 248 tis. Kč
    • •
  • 1 838 tis. Kč
    • •
  • AV ČR
Project

Exploring new roles for ADAR1 in cancer; generation of immunopeptidome, links with p53 and the effects of cancer treatment on ADAR1 activity. (GF22-26278K)

ADARs converts adenosine to inosine in double-stranded RNA. Inosine is one of the most abundant modifications found in RNA. Editing by ADAR1 is induced by interferon be used as biomarkers in cancer. We also want to determin...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 8 929 tis. Kč
    • •
  • 8 929 tis. Kč
    • •
  • GA ČR
Project

ADAR RNA editing; how immune systems and brains breach The Central Dogma (GX21-27329X)

ADAR1 RNA editing in dsRNA inhibits activation of innate immune responses. We of specific CNS transcripts. We plan bioinformatics projects across all ADAR RNA editing whether removing the dsRNA-activated Protein Ki...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 49 916 tis. Kč
    • •
  • 49 916 tis. Kč
    • •
  • GA ČR
Project

Structure and function of the Trypanosoma brucei guide RNA binding protein 21 and its complex with the guide RNA molecule (GP204/04/P191)

featuresincluding a uridine deletion/insertion type of RNA editing. This process, which steps of the RNA editing process has, therefore, a potential to be an efficient way represents fundamental process for proper...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 984 tis. Kč
    • •
  • 984 tis. Kč
    • •
  • GA ČR
Project

Defining the role of ADAR1 and RNA editing in protection from infectious disease (GA24-12635S)

Editing of RNA by ADAR1 is essential to prevent activation of immune responses by endogenous ‘self’ RNA. Particularly, ADAR1 prevents activation of cytosolic dsRNA sensors and RNA editing in protection fro...

Infectious Diseases

  • 2024 - 2026
    • •
  • 9 822 tis. Kč
    • •
  • 9 822 tis. Kč
    • •
  • GA ČR
Project

Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei (GA204/09/1667)

RNA editing is required for maturation of mitochondrial (mt) mRNAs) RNAs. Tandem affinity purification of the RNA-binding protein TbRGG1, involved provisionally named the mitochondrial RNA binding complex ...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 4 702 tis. Kč
    • •
  • 4 702 tis. Kč
    • •
  • GA ČR
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