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719 (0,13s) •

Project

Nanomechanics of RNA and DNA structural motifs (GA14-21893S)

RNA and DNA motifs are recurrent structural building blocks found formulated mechanical models of the motifs. RNA non-helical motifs such as internal loops of RNA and DNA motifs important...

BO - Biofyzika

  • 2014 - 2016
    • •
  • 2 668 tis. Kč
    • •
  • 2 668 tis. Kč
    • •
  • GA ČR
Project

Structural dynamics, molecular interactions and function of key RNA motifs (GA203/09/1476)

substitutions during evolution, analyze motif swaps in homologous RNAs, classify RNA base dynamics of RNA motifs and improve 2D predictions of internal RNA loops.   and function of large RNAs...

CF - Fyzikální chemie a teoretická chemie

  • 2009 - 2012
    • •
  • 2 812 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • GA ČR
Project

Mechanical properties of RNA and DNA structural building blocks (GA17-14683S)

Natural and artificial RNA and DNA structures are composed of recurrent of these motifs using theoretical methods and computer simulations. Statistical mechanical of cytosine methylation on DNA mechanics, and DNA with structural les...

BO - Biofyzika

  • 2017 - 2021
    • •
  • 4 017 tis. Kč
    • •
  • 3 756 tis. Kč
    • •
  • GA ČR
Project

Computational study of RNA multiple junctions localized in functionally important sites of the ribosome (KJB400040901)

The project is focused on study of ribosomal RNA multiple junctions complex molecules composed of RNA motifs/submotifs. These systems consist of non-standard pairs will be suggested. Characterization of ribosomal RNA

CE - Biochemie

  • 2009 - 2011
    • •
  • 717 tis. Kč
    • •
  • 717 tis. Kč
    • •
  • AV ČR
Project

Formation and dynamics of nucleic acid motifs involved in regulation of gene expression (GA202/09/0193)

of structural motifs and/or their complexes. Main accent will be put on employment will be concentrated to several families of NA structural motifs significant for natural and dynamic properties of the natural and chemically modifi...

BO - Biofyzika

  • 2009 - 2013
    • •
  • 12 186 tis. Kč
    • •
  • 12 186 tis. Kč
    • •
  • GA ČR
Project

Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei (GA204/09/1667)

provisionally named the mitochondrial RNA binding complex 1 because some putative subunit proteins contain motifs implicated in RNA metabolism. Preliminary resultsRNA editing is required for maturation of mitochon...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 4 702 tis. Kč
    • •
  • 4 702 tis. Kč
    • •
  • GA ČR
Project

Dynamic polymorphism of non-canonical nucleic acids structures in the intracellular space (GF24-10605K)

Dynamic transitions between B-DNA and tetraplex DNA structures, particularly G-quadruplexes and i-motifs, contributes to the regulatory control of genome integrity and gene expression. Formation of RNA G-quadruplexes contributes to ...

Biochemical research methods

  • 2024 - 2027
    • •
  • 10 419 tis. Kč
    • •
  • 10 203 tis. Kč
    • •
  • GA ČR
Project

Structural interpretation of the nuclear magnetic resonance spectroscopy parameters in nucleic acids and peptides (GPP208/10/P398)

Improving the current methodology structural interpretation of experimental NMR parameters for determining the important structural motifs in DNA, RNA and peptides (e.g. topology covalent linkages within the tertiary interactions) u...

CF - Fyzikální chemie a teoretická chemie

  • 2010 - 2012
    • •
  • 657 tis. Kč
    • •
  • 657 tis. Kč
    • •
  • GA ČR
Project

Novel DNA and RNA oligonucleotides with Phosphonothioate and Phosphonoamidate Internucleotide Linkages. (GA13-26526S)

) agonists/antagonists of TLR9 receptor (CpG motif-containing ONs), and (iii) effectors is the synthesis of monomers which, upon incorporation into DNA and RNA ONs, give rise......

CC - Organická chemie

  • 2013 - 2016
    • •
  • 11 970 tis. Kč
    • •
  • 11 970 tis. Kč
    • •
  • GA ČR
Project

The importance of having YS phosphorylated. Investigation of interaction between CTD and transcription elongation factor Spt6 (GA15-24117S)

Histone chaperon Spt6 is highly conserved and essential protein that functions in transcription elongation, chromatin maintenance, and RNA processing. Spt6 is required for recruitment of RNA processing factors to elongating RNA<...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 9 153 tis. Kč
    • •
  • 9 153 tis. Kč
    • •
  • GA ČR
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