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610 (0,142s) •

Project

The expression study of nucleolar upstream binding factor in malignant blood cells. (IZ1933)

9F - 9

  • 1994 - 1996
    • •
  • 1 240 tis. Kč
    • •
  • 1 790 tis. Kč
    • •
  • MZ
Project

New Generation of Antibacterial Agens (2B06065)

site of bacterial RNA polymerase (RNAP). RNAP is a key cellular enzyme that is required for the synthesis of ribosomal RNA, an essential part of the ribosome......

EB - Genetika a molekulární biologie

  • 2006 - 2011
    • •
  • 32 712 tis. Kč
    • •
  • 28 784 tis. Kč
    • •
  • MŠMT
Project

Structural studies of protein-RNA complexes involved in RNA quality control (GA204/08/1212)

To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings-the leftovers of RNA processing-but also improperly processed ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 6 990 tis. Kč
    • •
  • 2 490 tis. Kč
    • •
  • GA ČR
Project

Structural studies of protein-RNA complexes involved in RNA quality control (LA08008)

steps of information transfer. RNA maturation involves extensive processing that has a relatively high error rate. Cells have developed an RNA quality control mechanism which identifies improperly processed RNAs and subseq...

CE - Biochemie

  • 2008 - 2010
    • •
  • 1 833 tis. Kč
    • •
  • 1 833 tis. Kč
    • •
  • MŠMT
Project

Structural basis for transcription termination of nonpolyadenylated transcripts (IAA401630903)

RNA polymerases produce RNA transcripts by initiating and terminating RNA transcript. RNA Polymerase II transcribes not only mRNA but also a subset of small nuclear and small nucleoar RNAs, and a class of ...

CE - Biochemie

  • 2009 - 2011
    • •
  • 4 875 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • AV ČR
Project

Viral RNA modifications (GJ16-16358Y)

The vitally important methods for the sensitive analysis of RNA modifications enabling detailed studies of the chemical structure of various RNA entities are being developed only recently and they have never been applied to viral

CE - Biochemie

  • 2016 - 2016
    • •
  • 3 895 tis. Kč
    • •
  • 3 895 tis. Kč
    • •
  • GA ČR
Project

The molecular mechanisms of noncanonical 3' terminal RNA tailing and its role in the metabolism of coding and noncoding RNAs (GA20-19617S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional modifications, such as base modifications or nontemplated 3'-end tailing. The 3' terminal RNA uridylation plays diverse roles in RNA metabolism acting in both, p...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 10 824 tis. Kč
    • •
  • 10 806 tis. Kč
    • •
  • GA ČR
Project

Viral RNA modifications – Essential steps in Chemical Evolution of Protein Cofactors (LL1603)

studies, yet, there are surprisingly scarce data on RNA modifications or RNA analysis of RNA modifications enabling detailed studies of the chemical structure of various RNA entities are being developed only recen...

CE - Biochemie

  • 2017 - 2021
    • •
  • 48 762 tis. Kč
    • •
  • 48 762 tis. Kč
    • •
  • MŠMT
Project

Structural dynamics, molecular interactions and function of key RNA motifs (GA203/09/1476)

and function of large RNAs, such as the ribosome. The research will be conducted using of stochastic flexibilities of basic RNA building blocks. Both features are crucial for function of RNAs but are very difficult to asse...

CF - Fyzikální chemie a teoretická chemie

  • 2009 - 2012
    • •
  • 2 812 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • GA ČR
Project

Characterization of the RNA substrate repertoire of the human demethylase FTO (GA14-25884S)

Eukaryotic RNAs undergo a wide variety of posttranscriptional base modifications. Some of them are known to be essential for RNA folding, intermolecular of m6A remains largely enigmatic. Importantly, the RNA decoration by m...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 7 998 tis. Kč
    • •
  • 7 998 tis. Kč
    • •
  • GA ČR
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