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692 (0,171s) •

Project

Characterization of dynamical regions in RNA polymerase from Bacillus subtilis (GJ18-04197Y)

RNA polymerase is responsible for one of the key cellular mechanisms on a characterization of dynamical parts of the RNA polymerase that are specific for Gram positive for the biological function. Dynamics of two c...

Biochemistry and molecular biology

  • 2018 - 2022
    • •
  • 4 670 tis. Kč
    • •
  • 4 670 tis. Kč
    • •
  • GA ČR
Project

Inhibitors of Bacterial RNA Polymerase Based on Nucleotide Analogues (NR9138)

We propose to develop novel inhibitors of bacterial RNA polymerase. Inhibitors will be nucleotide analogues and target its active site.Techniques from molecular biology, organic chemistry, 3D modeling, and high throughput inhibitor ...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 9 025 tis. Kč
    • •
  • 8 481 tis. Kč
    • •
  • MZ
Project

Structural and functional study of flaviviral polymerases and comparison to related enzymes (GA21-25280S)

(Coronaviridae) pandemics. The utmost important enzyme for their replication is the RNA-dependent RNA-polymerase that is also a bona fide target for antivirals. Unfortunately will explore the ability of such compounds to i...

Health-related biotechnology

  • 2021 - 2023
    • •
  • 7 210 tis. Kč
    • •
  • 6 639 tis. Kč
    • •
  • GA ČR
Project

Analysis of anti-viroid antisense systém driven by RNA polymerase III promoter elements (ME 463)

The project is focusing on a) analysis of transcription and stability of chimeric antisense RNAs in plant extracts and on construction of new plant vectors conditions.The main purpose of the project is to develop new new antisense RNA

EB - Genetika a molekulární biologie

  • 2001 - 2002
    • •
  • 630 tis. Kč
    • •
  • 230 tis. Kč
    • •
  • MŠMT
Project

Structural basis for transcription termination of nonpolyadenylated transcripts (IAA401630903)

RNA polymerases produce RNA transcripts by initiating and terminating RNA transcript. RNA Polymerase II transcribes not only mRNA but also a subset of small nuclear and small nucleoar RNAs

CE - Biochemie

  • 2009 - 2011
    • •
  • 4 875 tis. Kč
    • •
  • 4 875 tis. Kč
    • •
  • AV ČR
Project

Development of in vitro transcription system for Corynebacterium glutamicum and characterization of RNA polymerase activity (GPP302/12/P633)

RNA polymerase (RNAP) from C. glutamicum and demonstrated its in vitro function RNA polymerase and sigma subunits will form the basis for a reliable in vitro......

EE - Mikrobiologie, virologie

  • 2012 - 2014
    • •
  • 2 430 tis. Kč
    • •
  • 2 430 tis. Kč
    • •
  • GA ČR
Project

The Delta Subunit of RNA Polymerase from Gram positive Bacteria (GA204/09/0583)

To efficiently fight bacterial diseases and infections, knowledge of the molecular mechanisms used by these organisms is required. Bacterial RNA polymerase (RNAP) is an essential multisubunit enzyme. Contrary to the well studied RNA...

EE - Mikrobiologie, virologie

  • 2009 - 2012
    • •
  • 6 639 tis. Kč
    • •
  • 6 639 tis. Kč
    • •
  • GA ČR
Project

Allosteric sites of SARS-CoV-2 RNA polymerase and exoribonuclease repair activity promising targets for novel antivirals (GA22-17118S)

into a molecular modulation of two enzymes of SARS-CoV-2 replication complex RNA-dependent RNA polymerase (RdRp) and Exoribonuclease (ExoN), which are critical for the viral lifecycle them to study their effect on regulati...

Organic chemistry

  • 2022 - 2024
    • •
  • 9 478 tis. Kč
    • •
  • 8 612 tis. Kč
    • •
  • GA ČR
Project

Analysis of anti-viroid antisense systems driven by RNA polymerase III promoter elements. (ME 067)

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 44 tis. Kč
    • •
  • 44 tis. Kč
    • •
  • MŠMT
Project

Deciphering the Cellular Role of HelD, a Helicase-like Protein Associated with Bacterial RNA Polymerase. (GA15-05228S)

Correct regulation of gene expression is key for survival of the cell. Bacterial RNA polymerase (RNAP) is the central enzyme of gene expression. The activity of RNAP can be altered by a number of factors, and these factors are criti...

EE - Mikrobiologie, virologie

  • 2015 - 2017
    • •
  • 8 323 tis. Kč
    • •
  • 8 323 tis. Kč
    • •
  • GA ČR
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