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64 (0,115s) •

Project

In vivo mammalian RNAi revival (GX20-03950X)

RNA interference (RNAi) is an ancestral antiviral innate immunity pathway abandoned during vertebrate evolution. The project seeks to understand how RNAi could be restored in vivo without significant negative effects and if augmente...

Biochemistry and molecular biology

  • 2020 - 2024
    • •
  • 48 132 tis. Kč
    • •
  • 48 132 tis. Kč
    • •
  • GA ČR
Project

RNA interference applications in chickens (GA523/04/0569)

We plan to use the recently described phenomenon of RNA interference (RNAi vectors bearing the RNAi hairpin casette for mounting the efficient RNAi in chicken RNAs into chicken embryos and developmental effects of the R...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2004 - 2006
    • •
  • 3 153 tis. Kč
    • •
  • 3 153 tis. Kč
    • •
  • GA ČR
Project

Development of chemical regulators of miRNA and RNAi pathways (GA13-29531S)

Here, we propose to use chemical biology to study miRNA and RNAi pathways. These pathways use small RNAs as sequence-specic guides for silencing gene expression. miRNAs of small molecules inhibiting or stimulating miRNA and RNAi pat...

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 8 056 tis. Kč
    • •
  • 8 056 tis. Kč
    • •
  • GA ČR
Project

Identification and RNAi silencing of aggregation pheromone production genes in the spruce-killing bark beetles (Ips typographus) (GA23-07916S)

by RNAi. Serie of behavioural assays with RNAi treated males will be performed to prove that RNAi silencing of IPDS can suppress beetles' aggregation behaviour.......

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 6 338 tis. Kč
    • •
  • 6 338 tis. Kč
    • •
  • GA ČR
Project

Analysis of specificity and efficacy of RNAi in tobacco BY-2 cell line (LTC18047)

The main objective of the presented project is to downregulate the transcription of auxin metabolizing enzymes (auxin oxidase and auxin amino acid conjugating Gretchen-Hagen 3 family member). In transgenic culture evaluate the efficacy and specificit...

Plant sciences, botany

  • 2018 - 2020
    • •
  • 2 884 tis. Kč
    • •
  • 2 884 tis. Kč
    • •
  • MŠMT
Project

Adaptor molecules in leukaemia (NR9108)

We will study a function of the adaptor molecules in leukaemia (analysing samples from childhood ALL patients as well as cell lines) using quantitative PCR (RQ-PCR), Western blotting and RNA interference (RNAi) methods. Pilot data suggest pr...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 878 tis. Kč
    • •
  • 3 833 tis. Kč
    • •
  • MZ
Project

Influence of inhibition of TEL/AML1 expression and function using RNAi and HDACi on leukaemic blast biology (GP301/03/D189)

function by introduction of a novel method - RNA interference (RNAi). We will test cells knocked-down by RNAi. Alternatively, we will utilise another......

FD - Onkologie a hematologie

  • 2003 - 2006
    • •
  • 695 tis. Kč
    • •
  • 695 tis. Kč
    • •
  • GA ČR
Project

Cyclooxygenases down-regulation and the influence on the gene expression (NR8760)

The aim of this study is to better understand the cellular gene expression changes upon the RNA interference (RNAi) mediated down-regulation of COX1 resp. COX2 gene expression. The corresponding cell-lines with COX1 resp. COX2 gene expressio...

EB - Genetika a molekulární biologie

  • 2006 - 2009
    • •
  • 6 423 tis. Kč
    • •
  • 6 370 tis. Kč
    • •
  • MZ
Project

Forms of gamma-tubulin and their interactions with proteins controlling cytokinesis, cell cycle and polarity. (IAA500200719)

Downregulation by RNAi showed previously that gamma-tubulin is essential for nucleation of microtubules from dispersed sites in acentrosomal plant cells but also revealed other as yet not defined roles for gamma-tubulin in cytokinesis and ce...

EF - Botanika

  • 2007 - 2011
    • •
  • 4 596 tis. Kč
    • •
  • 4 596 tis. Kč
    • •
  • AV ČR
Project

Regulatory mechanisms of growth and apoptosis of primary leukemia progenitor/stem cells. (NR8317)

The project will focus on the mechanisms of TRAIL-induced apoptosis and on the identification of key molecules responsible for the regulation of TRAIL-induced apoptosis of primary leukemia cells using in vitro and in vivo models of leukemia cell grow...

FD - Onkologie a hematologie

  • 2005 - 2008
    • •
  • 9 166 tis. Kč
    • •
  • 8 849 tis. Kč
    • •
  • MZ
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