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Projects

13 projects (0,107s) •

Project

Supramolecular chirality of nucleic acids (GA16-04902S)

), vibrational circular dichroism (VCD) and Raman optical activity (ROA)) are ideal tools chirality of nucleic acid systems. VCD and ROA methodologies will be adapted and applied......

BO - Biofyzika

  • 2016 - 2018
    • •
  • 2 674 tis. Kč
    • •
  • 2 428 tis. Kč
    • •
  • GA ČR
Project

Interactions of disulfide groups in peptide/ protein molecules - complementary use of electronic and vibrational optical activity (GAP205/10/1276)

optical activity - ROA) under the circumstances when more than one disulphide group in Raman and particularly ROA spectra....

BO - Biofyzika

  • 2010 - 2014
    • •
  • 2 241 tis. Kč
    • •
  • 2 241 tis. Kč
    • •
  • GA ČR
Project

Synthesis and Characterization of Lanthanide-Luminescence Probes for Biomolecular Raman Spectroscopy and Imaging (GA23-05378S)

(ROA) spectrometer greatly facilitates analysis of chiral systems. We aim. Their spectroscopic response will be monitored by the ROA-CPL methodology, and their potential......

Biophysics

  • 2023 - 2025
    • •
  • 6 286 tis. Kč
    • •
  • 6 258 tis. Kč
    • •
  • GA ČR
Project

Conformational flexibility of peptides in solution (GA202/07/0732)

the project is based mainly on Raman Optical Activity (ROA) and Raman scattering that can experiments. Interpretation of Raman and ROA spectra will be based on advanced spectral......

BO - Biofyzika

  • 2007 - 2009
    • •
  • 3 069 tis. Kč
    • •
  • 3 069 tis. Kč
    • •
  • GA ČR
Project

Development of Lanthanide Raman Probes for Biomedical Analyses and Imaging (GJ19-05974Y)

detected on an ROA (Raman optical activity) spectrometer, simultaneously with the Raman achiral lanthanide complexes will be prepared, then the ROA-CPL methodology assisted......

Biophysics

  • 2019 - 2022
    • •
  • 5 988 tis. Kč
    • •
  • 5 988 tis. Kč
    • •
  • GA ČR
Project

Optical activity and conformation of disulphide bridges in peptides and proteins (GA203/07/1335)

Using several model compounds we will establish and test a relation between three dimensional structure and vibrational optical activity (mainly Raman optical activity-ROA) of the disulphide group, which is difficult to study using classical...

CF - Fyzikální chemie a teoretická chemie

  • 2007 - 2009
    • •
  • 2 066 tis. Kč
    • •
  • 2 066 tis. Kč
    • •
  • GA ČR
Project

Poly-β-malic acid and its role as a possible primitive predecessor of nucleic acids (LTAUSA18085)

The aim of the project will be to confirm the existence of a double strand hydrogen bonded form of poly-β-L-malic acid, to examine the ability to generate a simple genetic alphabet with synthetically prepared β-linked oligomers formed by D-malic acid...

Biophysics

  • 2019 - 2022
    • •
  • 3 111 tis. Kč
    • •
  • 3 111 tis. Kč
    • •
  • MŠMT
Project

Pharmacrime – forensic identification of prohormones and counterfeid medicine (VJ01010043)

counterfeits (IR, Raman, MS, ELISA, LFIA, ECD and ROA) and identifying/quantifying...

Forensic science

  • 2021 - 2025
    • •
  • 38 515 tis. Kč
    • •
  • 38 515 tis. Kč
    • •
  • MV
Project

Development of spectroscopic methods for structural studies of biomolecules (LH11033)

. Specific objectives include 1) Adapt ROA methodology for biologically relevant peptide...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2014
    • •
  • 3 312 tis. Kč
    • •
  • 3 312 tis. Kč
    • •
  • MŠMT
Project

Elucidation of the structure and interactions of glycoconjugates and glycans using vibrational spectroscopy (GA16-00270S)

Glycans are carbohydrate parts of glycoproteins, glycolipids, or proteoglycans often determining their function. Glycans involve in protein folding, protein clearance, cell adhesion, receptor binding, receptor activation and many other processes. The...

BO - Biofyzika

  • 2016 - 2018
    • •
  • 7 752 tis. Kč
    • •
  • 6 507 tis. Kč
    • •
  • GA ČR
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