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5 350 (0,1s) •

Project

Introduction of in vitro contracture test, genetic and bioptical eyamination for the diagnosis of sesceptibility to malignant hyperthermia (ND6865)

Introduction of in vitro contracture test for diagnosis of malignant hyperthermia along with genetic examination of the pacient and his family and subsequent bioptical examination of the muscle biopsy.......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 920 tis. Kč
    • •
  • 1 900 tis. Kč
    • •
  • MZ
Project

Activation of pig oocytes - the role of inositol trisphosphate receptors, ryanodine receptors, calmodulin and protein kinase C (GA524/99/0301)

The aim of this study is to investigate the processes involved in the regulation of the exit of pig oocytes from the meiotic metaphase II stage. The aims of this study are to test the following hypotheses: 1) If the two-storey model for Ca2+...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 1999 - 2001
    • •
  • 1 087 tis. Kč
    • •
  • 1 087 tis. Kč
    • •
  • GA ČR
Project

Role of Lineage Specific Transcription Factors GATA-1 and PU.1 in Hematopoietic Commitment and Leukemogenesis (GA301/06/1093)

GATA-1 and myeloid PU.1, is thought to transcriptionally regulate lineage commitment in chromatin. PU.1 plays a role in cancer: high levels of transcription factor PU.1 has beenshown to cause erythroleukemia where...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 5 021 tis. Kč
    • •
  • 4 989 tis. Kč
    • •
  • GA ČR
Project

The study of relation between the activity of type - V collagenase and level of s-ICAM1 and s-VCAM1 in sera and synovial fluids to the prognosis of rheumatoid arthritis (NK6332)

A study will be made of the content and activity of gelatinase B and the levels of the soluble forms of immunoglobulins ICAM-1 and VCAM-1 in the blood serum and in the synovial fluid of patients with early rheumatoid arthritis. In t...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 1 831 tis. Kč
    • •
  • 1 831 tis. Kč
    • •
  • MZ
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are weak inducers of IFN-I. Exposure of pDCs to HIV-1-infected lympho...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Novel regulatory mechanisms of transcription factors PU.1 and GATA-1 in leukemogenesis. (GPP301/12/P380)

determinants such as transcription factor PU.1 regulating most of the hematopoietic target genes. Production of mature blood elements requires connecting PU.1 with secondary determinants such as GATA-1 and other lineage sp...

FD - Onkologie a hematologie

  • 2012 - 2016
    • •
  • 3 726 tis. Kč
    • •
  • 3 726 tis. Kč
    • •
  • GA ČR
Project

Genetic predisposition to osteoporosis. (NB7380)

An analysis of the association between common polymorphisms in the transforming growth factor beta -1, plasminogen-activator inhibitor and collagen type 1 genes and osteoporosis.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 574 tis. Kč
    • •
  • 2 573 tis. Kč
    • •
  • MZ
Project

1-fluoro-1-lithioalkanes and 1-fluoro-1lithio-1-alkanes - synthesis, stability study and synthetic applications (GA203/99/1630)

The target of the project is the synthesis of 1-fluoro-1-lithioalkanes of general formula XYCFLi and of 1-fluoro-1-lithio-1-alkenes of general formula WZC=CFLi. The stability of these compounds will be stu...

CC - Organická chemie

  • 1999 - 2001
    • •
  • 965 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

The role of DNA methylation and histone modifications in the establishment and maintenance of HIV-1 latency (GP204/08/P616)

for eradication of HIV-1 infection. We found that CpG methylation of the HIV-1 promoter in 5?LTR is not needed for establishment of HIV-1 latency but controls the stringency oftranscriptional silencing. HIV-1 late...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 500 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • GA ČR
Project

Identification of the subtypes and study of genetic variants of HIV-1 in the Czech Republic (NI5174)

Genetic characterization of HIV-1 strains in the Czech Republic. Determination of genetic subtypes, strains resistant to antiretroviral therapy. Comparison of genotypes of the selected HIV-1 strains with their biological properties....

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 3 095 tis. Kč
    • •
  • 1 374 tis. Kč
    • •
  • MZ
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