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4 (0,118s)

Project

Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure (2B08061)

occurence of RyR2 gene polymorphisms will be investigated compared to a control group to assess the role of RyR2 in arrhythmogenesis. Working hypothesis is based on fact that in catecholaminergic polymorphic ventricular tachycardia...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2008 - 2011
  • 7 594 tis. Kč
  • 6 651 tis. Kč
  • MŠMT
Project

Reprogramming of DMD-patient cells into cardiomyocytes - insights into molecular pathology of dilated cardiomyopathy (7AMB13FR011)

patients at different ages. Aim 2: Isolate cardiac RyR2 channels from properties of RyR2 macromolecular complex, Aim 3: Test drugs such as rycals (Ca channel conformation of RyR2 channels at a single cell and a single chan...

EB - Genetika a molekulární biologie

  • 2013 - 2014
  • 108 tis. Kč
  • 108 tis. Kč
  • MŠMT
Project

Functional assessment of genetic variants in clinically “true” cases of idiopathic ventricular fibrillation in vitro and in silico modelling to reveal the arrhythmogenic mechanism (NU22-02-00348)

related to the familial electric cardiac diseases, namely in KCNH2 and RYR2 for familial electric cardiac diseases (KCNQ1, KCNH2, SCN5A, RYR2). The functional analysis in the KCNH2 gene (S1021Qfs*98 and A228V) and a variant in the ...

Cardiac and Cardiovascular systems

  • 2022 - 2025
  • 14 750 tis. Kč
  • 14 750 tis. Kč
  • MZ
Project

Modeling DMD-related dilated cardiomyopathy using induced pluripotent stem cells-derived cardiomyocytes (GA13-19910S)

in cardiomyocytes (CMs). Recent works have suggested that Ca leak via ryanodine receptor (RyR2 alternative model. We also hypothesize that Ca leak through RyR2 in DMD-CMs contributes......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
  • 6 415 tis. Kč
  • 6 415 tis. Kč
  • GA ČR
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