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9 (0,101s)

Project

Mechanisms of radioresistance of prostate cancer cells (GA13-17658S)

the molecular mechanisms of radioresistance of primary and metastatic CaP in relation expression. Our understanding of radioresistance of CaP is fundamental for future efforts......

EB - Genetika a molekulární biologie

  • 2013 - 2016
  • 9 124 tis. Kč
  • 9 124 tis. Kč
  • GA ČR
Project

New therapeutic targets in overcoming radioresistance Systematic identification of genes driving response to radiation through the integration of functional genomics and transcriptomic profiling (NW24-03-00221)

of radioresistance, a characteristic feature of recurrent GBM, are not yet fully understood. Radioresistance is therefore a major topic of current concern in oncology research by the development of radioresistance in tumor...

Oncology

  • 2024 - 2027
  • 14 956 tis. Kč
  • 14 956 tis. Kč
  • MZ
Project

Analysis and targeting of DNA damage signaling and repair mechanisms in glioblastomas and glioblastoma stem cells as a strategy to elucidate pathogenesis and search for individualized targeted treatments combined with standard therapy (NT11065)

) in glioblastoma, aiming at better understanding of molecular pathogenesis, radioresistance...

FD - Onkologie a hematologie

  • 2010 - 2014
  • 8 112 tis. Kč
  • 8 112 tis. Kč
  • MZ
Project

New biological methods of the received dose determination (2B08028)

In case of accidental irradiation of a human body (irradiation accidents, inappropriate manipulation with radioactive waste, terroristic attack) the medical personnel have to cope with the fundamental task to determine the received dose of ionizing r...

DN - Vliv životního prostředí na zdraví

  • 2008 - 2010
  • 6 339 tis. Kč
  • 4 490 tis. Kč
  • MŠMT
Project

Usage of tissue microRNAs for identification of patients who will benefit from the adjuvant radiotherapy after surgical resection of atypical meningioma (NV19-03-00559)

deregulated in meningioma and to be involved in processes associated with radioresistance...

Oncology

  • 2019 - 2023
  • 8 319 tis. Kč
  • 8 289 tis. Kč
  • MZ
Project

Hidden Gems of Microbial Diversity Geothermally Heated Groundwaters as a Source of Phylogenetically Novel and Metabolically Rare Prokaryotes (GA25-15226S)

of the genetic basis of the radioresistance of isolated pure cultures, provide a deeper...

Microbiology

  • 2025 - 2027
  • 14 924 tis. Kč
  • 13 361 tis. Kč
  • GA ČR
Project

Characterizing & modifying complex response of head & neck tumor cells to different radiations - a step forward to combined personalized radiotherapy (GA16-12454S)

Head and neck tumors are aggressive neoplasms located close to vital tissues. However, only about 60% of tumors respond to noninvasive chemo-radiotherapy, the failure of which significantly worsens results of the subsequent rescue surgery as compared...

FD - Onkologie a hematologie

  • 2016 - 2018
  • 9 789 tis. Kč
  • 9 033 tis. Kč
  • GA ČR
Project

Molecular-genetic markers for prediction of radiotherapy response in head and neck cancer (NV16-29835A)

Currently, there is no clinical marker which allows a pre-therapeutic selection of patients with head and neck tumors that would profit more from the conservative therapy or primary surgery, respectively. We meaningfully contribute to solution of thi...

FD - Onkologie a hematologie

  • 2016 - 2019
  • 17 558 tis. Kč
  • 16 921 tis. Kč
  • MZ
Project

FMISO-based protocol for adaptive radiotherapy in head and neck cancer (NU22-03-00435)

. These radioresistant regions can be detected with FMISO PET/CT. It has also been demonstrated...

Oncology

  • 2022 - 2025
  • 9 858 tis. Kč
  • 9 858 tis. Kč
  • MZ
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