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47 (0,124s) •

Project

Study of the preparation and of the properties of ruthenium hydrogenation catalysts, perspectivities of their utilization in synthesis of fine chemicals (GA104/97/0890)

The proposed project is focused on the study of preparation of ruthenium recent results and literature sources show that application of ruthenium catalysts of organic compounds. Metal ions modified ruthenium catalysts, ...

CI - Průmyslová chemie a chemické inženýrství

  • 1997 - 1999
    • •
  • 1 519 tis. Kč
    • •
  • 1 095 tis. Kč
    • •
  • GA ČR
Project

The development of ruthenium antitumor compounds (OC D8.50)

was tested using model tumors, the ruthenium complexes yielded promising results. It has been shown that several ruthenium complexes are active in some model colorectal tumors resistant to cisplatin and its analogues and also that ...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 6 030 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • MŠMT
Project

Biophysical analysis of DNA interactions with antitumor ruthenium complexes (GA204/97/P028)

ruthenium complexes. Ruthenium complexes with dimethylsulfoxide ligands and complexes. The biological properties of the ruthenium complexes chosen for our studies are interesting of the platinum group including rutheni...

CE - Biochemie

  • 1997 - 1999
    • •
  • 659 tis. Kč
    • •
  • 479 tis. Kč
    • •
  • GA ČR
Project

Structure and properties of paramagnetic ruthenium complexes for designing new anticancer drugs (GA15-09381S)

We propose to study novel candidates for ruthenium anticancer drugs based on ruthenium complexes protected by cucurbit[n]uril and bambus[n]uril cavitands. The ruthenium compounds will be synthesized and combined with cavita...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
    • •
  • 5 685 tis. Kč
    • •
  • 5 685 tis. Kč
    • •
  • GA ČR
Project

Recognition of DNA modified by antitumor platinum and ruthenium complexes by zinc-finger proteins and topoisomerases (KJB400040601)

This application proposes to examine efficiency of various conventional and novel antitumor platinum and ruthenium coordination complexes to eject zinc from effectiveness of theplatinum and ruthenium compounds from the viewpoint eff...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • AV ČR
Project

The effect of sigma receptors on contractility and membrane currents in mammalian myocardium (GA305/98/P206)

ruthenium complexes. Ruthenium complexes with dimethylsulfoxide ligands and complexes. The biological properties of the ruthenium complexes chosen for our studies are interesting of the platinum group including rutheni...

ED - Fyziologie

  • 1998 - 2001
    • •
  • 456 tis. Kč
    • •
  • 456 tis. Kč
    • •
  • GA ČR
Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

Intracellular and extracellular targets for antitumor of ruthenium complexes (OC D20.003)

The proposed cooperative study has three main goals. First, we want to examine a number of complexes of ruthenium and of other group VIII transition metals in order and the biological relevance for the interaction of ruthenium compl...

CE - Biochemie

  • 2002 - 2005
    • •
  • 3 265 tis. Kč
    • •
  • 1 326 tis. Kč
    • •
  • MŠMT
Project

Cellular and molecular pharmakology of platinum and ruthenium anticancer drugs (GA305/01/0418)

The need for improved clinical protocols has prompted a search for new metal-based chemotherapeutic agents, such as those based on platinum and ruthenium compounds as well as a more complete understanding of the cellular mechanisms underlyin...

FR - Farmakologie a lékárnická chemie

  • 2001 - 2003
    • •
  • 5 234 tis. Kč
    • •
  • 2 854 tis. Kč
    • •
  • GA ČR
Project

Structure, recognition, and processing of DNA damage by metal-based compounds of biological significance (OC08003)

Data will be obtained describing structural and biochemical properties of DNA modified by antitumor platinum and ruthenium complexes. These findings will be exploited for improvement of structure-pharmacological relationships of metallodrugs...

BO - Biofyzika

  • 2008 - 2011
    • •
  • 1 791 tis. Kč
    • •
  • 1 791 tis. Kč
    • •
  • MŠMT
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