All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

6 506 (0,082s) •

Project

The SMC5/6 complex in nucleome organization (LTC20033)

a) Characterization of activities of the SMC5/6 complexes b) Determination of the chromatin localization and dynamics of SMC5/6 c) Identification of chromatin loops dependent on SMC5/6 ...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 7 289 tis. Kč
    • •
  • 7 289 tis. Kč
    • •
  • MŠMT
Project

Role of the SMC5/6 complex and its interaction partners in DNA damage repair (GA20-05095S)

are amongst the key factors maintaining genome integrity. Particularly, the SMC5/6 complex is involved in repair of genomic DNA. However, it is still not clear how SMC5/6 participates in DNA repair. There...

Plant sciences, botany

  • 2020 - 2022
    • •
  • 9 153 tis. Kč
    • •
  • 9 120 tis. Kč
    • •
  • GA ČR
Project

Role of Nse1/Nse3/Nse4, E3-ubiquitin ligase, in genome stability (GA18-02067S)

maintenance. The SMC5/6 complex is required for chromatin organization, replication, the way how SMC5/6 is involved in these processes remains unclear. Interestingly, its. In this project, we aim to ident...

Cell biology

  • 2018 - 2022
    • •
  • 7 276 tis. Kč
    • •
  • 6 790 tis. Kč
    • •
  • GA ČR
Project

Role of Nse proteins, subunits of the SMC5/6 complex, in stabilization and processing of stalled replication forks (GA13-00774S)

The SMC5/6 complexes are implicated in many processes like chromosome and particularly into interplay between SMC5/6 and Fml1(FancM) helicase, which is involved). They are composed of 6 conserved ...

CE - Biochemie

  • 2013 - 2016
    • •
  • 7 346 tis. Kč
    • •
  • 7 346 tis. Kč
    • •
  • GA ČR
Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

responsible, including a key role for the SMC5/6 complex. Given the enigmatic role of SMC5/6 and other involved factors in restricting viral DNA transcription, a deeper......

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 260 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
Project

Characterization of MAGE proteins cofactors for E3 ubiquitin ligases? (IAA501630902)

The MAGE (Melanoma antigen) family consists of 35 proteins in humans that contain a "MAGE homology domain" (MHD) but have widely differing functions. The Smc5-6 complex, which functions in DNA repair, consists of MAGEG1-Nse...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 893 tis. Kč
    • •
  • 2 893 tis. Kč
    • •
  • AV ČR
Project

Nuclear phase of polyomavirus infection virus restriction and infection establishment. (GA19-14445S)

experiments, Sp100 or Sp110 proteins and also Smc5/6 complex, co-localising with PyV...

Virology

  • 2019 - 2022
    • •
  • 10 275 tis. Kč
    • •
  • 10 271 tis. Kč
    • •
  • GA ČR
Project

Rigid cyclodextrin duplexes synthesis and study of inclusion complexes (GA203/06/1550)

The proposal deals with the synthesis of rigid dimers composed of +-cyclodextrin units bridged at 6A - 6'A' and 6D - 6'D positions. First, methods allowing in the natureof the linker. Consequently, propensity of the duplexes to ...

CC - Organická chemie

  • 2006 - 2008
    • •
  • 1 161 tis. Kč
    • •
  • 1 161 tis. Kč
    • •
  • GA ČR
Project

Interactions of platinum metal complexes containing substituted 6-benzylaminopurines as ligands with DNA and microsomal cytochromes P450 (GPP208/10/P466)

of platinum metal complexes derived from cisplatin with substituted 6-benzylaminopurines as non-leaving ligands has been prepared. Considering character of these complexes the DNA binding activity is expected. In addition,...

BO - Biofyzika

  • 2010 - 2014
    • •
  • 1 462 tis. Kč
    • •
  • 1 462 tis. Kč
    • •
  • GA ČR
Project

Synthesis of helicenes via cycloisomerization of biphenylylnaphthalene and 1,8-diarylnaphthalene derivatives (GAP207/10/1124)

of modular approach for synthesis of [6]helicenes, recently developed in our group, to chemistry of aza- and diaza[6]helicenes. Complexation properties of heterohelicenes to transition metals will be also studied. Furtherm...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 2 016 tis. Kč
    • •
  • 2 016 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 6 506