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Projects

25 projects (0,117s) •

Project

Analysis of STAT 1 and STAT 3 mediated cytokine signaling in normal and cancer cells (GA301/03/0370)

STATs are multi protein transducers and transcriptional factors the STAT 1 and STAT 3 levels in normal as well as tumor cells, and to establish whether of STAT 1/STAT 3 in the transcription of p21WAF1/CIP1...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 4 074 tis. Kč
    • •
  • 3 108 tis. Kč
    • •
  • GA ČR
Project

The role of STAT 5 protein in cytokine-mediated signaling in normal and malignant human breast epithelium (KJB502070601)

JAK/STAT signaling pathway operating downstream of cytokine receptors some questions arising from the idea that STAT 5 (signal transducer and activator epithelial cells and its functional abnormalities of STAT 5 might influ...

EB - Genetika a molekulární biologie

  • 2006 - 2007
    • •
  • 590 tis. Kč
    • •
  • 590 tis. Kč
    • •
  • AV ČR
Project

Molecular and functional perturbances of STAT/SOCS signaling pathways in breast cancer cells and their biological consequences. (GA301/06/0912)

The signal transducers and activators of transcription (STATs genes in thenucleus. Various STAT/SOCS abnormalities have been found in cancer cells thatoccur within STAT/SOCS signaling pathways in breast cancer cells and to ...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 931 tis. Kč
    • •
  • 3 931 tis. Kč
    • •
  • GA ČR
Project

The study of molecular defects of cancer cell in the transduction pathways of interferon signals mediated by STAT 1/SOCS 3 proteins and their significance for the prediction of tumor sensitivity (NC7139)

Project intends to explore whether and to what extend cancer-related impaired interferon transduction pathways ensured by STAT 1 and SOCS 3 protein functions The level of STAT 1/ SOCS 3 proteins, their mRNAs, and STAT 1 pho...

EC - Imunologie

  • 2002 - 2004
    • •
  • 6 107 tis. Kč
    • •
  • 6 059 tis. Kč
    • •
  • MZ
Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-induced senes...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Analysis of expression of STAT, JAK and SOCS in glial tumors of brain and in carcinomas of breast and prostate gland. Correlation with grading, expression of steroid receptors and expression (1A8244)

Disruption of signaling of JAK/STAT/SOCS may be the cause of failure of immune surveillance and may participate in development and invasion of various tumors, including carcinomas of prostate gland, breast and glial tumors of brain. The aim ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 665 tis. Kč
    • •
  • 1 419 tis. Kč
    • •
  • MZ
Project

The role of the STAT signalling pathway in the rat circadian system (GAP303/12/1137)

of transcription (STAT) proteins in the SCN of rats. In other biological models, STAT proteins the presumed role of STAT proteins in the circadian system. Our aim is to find out whether......

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 3 757 tis. Kč
    • •
  • 3 757 tis. Kč
    • •
  • GA ČR
Project

Molecular and functional cancer-associated perturbances in JAK/STAT/SOCS proteins and in their target genes expression (NR8341)

The study intends to analyze molecular and functional cancer-specific abnormalities in STAT/SOCS signaling proteins and in the expression of their target genes which might represent new tumor markers and be of help in immunotherapeutic strat...

EC - Imunologie

  • 2005 - 2008
    • •
  • 12 627 tis. Kč
    • •
  • 12 366 tis. Kč
    • •
  • MZ
Project

The role and abnormalities of STAT1 in mediating the immunological and antiproliferative effects of Interferon-alpha in malignant melanoma (GA301/00/0564)

of signal transducer and activator of transcription STAT 1 protein for mediating therapy. To accomplish this goal polyclonal and monoclonal antisera to STAT 1 protein and its phosphorylated forms will be developed. STAT 1 ...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 360 tis. Kč
    • •
  • 3 040 tis. Kč
    • •
  • GA ČR
Project

Molecular diagnosis of the lymphoproliferative disorders with methods of analysis of DNA, RNA and proteins application of results in clinical praxis (NR8443)

and chemoresistance STATs play central role in cytokine signaling and influence proliferation and apoptosis of lymphocytes. Identification of the defects in STAT phosphorylation......

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 222 tis. Kč
    • •
  • 2 207 tis. Kč
    • •
  • MZ
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