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15 (0,153s) •

Project

Label-free, real-time biosensing of dynamic cellular activity on a chip (GA24-10671S)

to signalling and drugs. Conventional methods to study the secretome (the collection need for ultra-sensitive and real-time monitoring of changes in the secretome permeability. For the real-time monitoring of larger molecules in th...

Polymer science

  • 2024 - 2026
    • •
  • 16 219 tis. Kč
    • •
  • 11 606 tis. Kč
    • •
  • GA ČR
Project

Secretomics exploration of intercellular communicators between parasites and their hosts (GA23-07990S)

Secretomes produced by parasites can modulate the immune system of their host. Available studies performed exclusively in mammalian models show that they are upregulated carriers of molecules responsible for cell-cell crosstalk across the ki...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 995 tis. Kč
    • •
  • 7 995 tis. Kč
    • •
  • GA ČR
Project

Paracrine effect of mesenchymal stem cell-secretome and its modification for the treatment of spinal cord injury (GA17-03765S)

Paracrine action is a major mechanism attributed to mesenchymal stem cells (MSCs) beneficial effects in neural repair. MSCs produce a range of cytokines, chemokines and growth factors that have immunomodulatory, neuroprotective and neurotrophic effec...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2019
    • •
  • 5 238 tis. Kč
    • •
  • 4 851 tis. Kč
    • •
  • GA ČR
Project

New signaling pathways induced in mast cells by cholesterol-dependent cytolysins (GA23-07736S)

, pharmacological, and genetic approaches, combined with transcriptomics and secretome analysis...

Immunology

  • 2023 - 2025
    • •
  • 9 951 tis. Kč
    • •
  • 9 657 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of Trichomonas vaginalis impact on Lactobacillus species Implication for Vaginal Microbiota Dynamics (GA25-16906S)

) dynamic T. vaginalis secretome, (iii) changes in the composition of surface proteins...

Cell biology

  • 2025 - 2027
    • •
  • 10 605 tis. Kč
    • •
  • 10 605 tis. Kč
    • •
  • GA ČR
Project

Identification and functional characterization of bioactive molecules produced by entomopathogenic nematodes (GA23-06457S)

is the identification of molecules in the secretome of the nematode Heterorhabditis bacteriophora...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 987 tis. Kč
    • •
  • 9 987 tis. Kč
    • •
  • GA ČR
Project

Development of tissue-specific biological scaffolds for the neural tissue repair (GA15-01396S)

or their secretomes and rehabilitation. The project will allow the implementation of methods...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2017
    • •
  • 3 917 tis. Kč
    • •
  • 3 917 tis. Kč
    • •
  • GA ČR
Project

Intrathecal and intramuscular application of mesenchymal stem cells and their secretome in the treatment of amyotrophic lateral sclerosis (GA15-06958S)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with no effective therapy. Our project will compare the effect of repeated intrathecal application of human mesechymal stromal cells (MSCs) and MSCs-conditioned medium (CM...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2019
    • •
  • 7 413 tis. Kč
    • •
  • 7 413 tis. Kč
    • •
  • GA ČR
Project

Inhibition of JAK/STAT3 signalling pathway in cancer therapy (GA18-14259S)

and its acceleration by senescent cells and to modify an immunophenotype and secretome...

Medicinal chemistry

  • 2018 - 2022
    • •
  • 11 770 tis. Kč
    • •
  • 11 355 tis. Kč
    • •
  • GA ČR
Project

Development of brain organoid models to study the role of cellular senescence in the pathogenesis of glioblastoma (GA24-11357S)

cellular senescence, the composition of the senescent secretome concerning...

Oncology

  • 2024 - 2026
    • •
  • 12 422 tis. Kč
    • •
  • 11 822 tis. Kč
    • •
  • GA ČR
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