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7 904 (0,109s) •

Project

Immune response to infection with the microsporidian Encephalitozoon cuniculi, in immunocompetent and SCID mice (IAA6022101)

of the immune system. Adoptive transfers of defined lymphocyte subpopulations into mice with severe combined immunodeficiency (SCID) will elucidate the role of these subsets in immunodeficient hosts. The ...

EC - Imunologie

  • 2001 - 2003
    • •
  • 2 636 tis. Kč
    • •
  • 1 276 tis. Kč
    • •
  • AV ČR
Project

Mechanism involved in enteropathy and diabetes participation of food and bacterial antigens in triggering of autoimmunity (GA306/98/0433)

isolated from mucosal compartment of NOD and athymic mice into SCID ( severe combined immunodeficient ) recipient mice will be performed and its effect analysed present in the gut of animal models of diab...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2000
    • •
  • 2 609 tis. Kč
    • •
  • 2 441 tis. Kč
    • •
  • GA ČR
Project

The role of IFN-gamma in the immune response against microsporidial infection (GP524/03/D167)

will by elucidated using an adoptive transfer of lymphocyte subpopulations to severe combined immunodeficient (SCID) mice, specific depletion of lymphocyte subsets, or interferon gammaMicrosporidia have been recen...

EC - Imunologie

  • 2003 - 2006
    • •
  • 1 087 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Immune response of mice to infection with different gastric cryptosporidia from mammals (KJB500960701)

and immunodeficient mouse strains in combination with adoptive transfer experiments. We intendCryptosporidia have been found to be causative agents of clinical diseases in immunocompetent and immunodeficient patients. Acti...

EC - Imunologie

  • 2007 - 2009
    • •
  • 1 616 tis. Kč
    • •
  • 1 616 tis. Kč
    • •
  • AV ČR
Project

Fc receptors on immune cells and clinical manifestation in patients with primary immunodeficiency (NI7138)

The relation of membrane structures, particularly Fc gamma receptors to the severity of clinical manifestation and to the efficacy of gammaglobulin therapy in patients with primary immunodeficiency will be analysed in the study. A p...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2002 - 2004
    • •
  • 2 881 tis. Kč
    • •
  • 2 841 tis. Kč
    • •
  • MZ
Project

Acute and chronic colitis induced by DSS and transfer by CD4+CD45RBhigh T lymphocytes in immunodeficient (SCID) mice the role of microflora, using probiotics. (GA303/04/0849)

The aim of this project is study of the development intestinal inflammation/ulcerative colitis and the role of the infection at the development this disease. Transfer model CD4-CD45RB high T lymphocytes and Dextran sulfate treatment of immunodefi...

ED - Fyziologie

  • 2004 - 2006
    • •
  • 2 228 tis. Kč
    • •
  • 2 228 tis. Kč
    • •
  • GA ČR
Project

Circulating microvesicles (microparticles and exosomes) for diagnosis of gynecological malignancies (NT12248)

carcinogenesis - immunodeficient mice engrafted with human tumors.. To identify cancer specific biomarkers we propose to combine molecular analysis......

FK - Gynekologie a porodnictví

  • 2011 - 2015
    • •
  • 6 321 tis. Kč
    • •
  • 6 321 tis. Kč
    • •
  • MZ
Project

The development of chimeric antigen receptors for the immunotherapy of lymphoma. (NT14030)

autologous tumor cells in vitro and also in vivo using the immunodeficient mice and we will test them in vitro and in vivo using immunodeficient mice.......

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 7 435 tis. Kč
    • •
  • 7 435 tis. Kč
    • •
  • MZ
Project

Study and characterization of tumour cell lines of primary squamous cell carcinoma of the head and neck and their malignant potential. (NT14337)

It will be conducted a clinical trial, which aims to analyze the aggressiveness and malignant potential of tumour cells in squamous cell carcinoma of the head and neck in the immunodeficient mouse model and further analyze known tumour marke...

FF - ORL, oftalmologie, stomatologie

  • 2013 - 2015
    • •
  • 9 559 tis. Kč
    • •
  • 9 559 tis. Kč
    • •
  • MZ
Project

Drosophila model of adenosine deaminase deficiency (GA204/04/1205)

of enzyme activity lead to a combined immunodeficiency (SCID) in humans and perinathal lethality in mice. It is clear that those pathological effects are caused......

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 785 tis. Kč
    • •
  • 2 785 tis. Kč
    • •
  • GA ČR
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