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6 755 (0,15s) •

Project

New approaches to Chimeric Antigen Receptor T cells analysis of RASAL3 protein function and identification of novel CAR-T activity-modifying genes (GA22-35273S)

function of RASAL3, a negative regulator of T-cell signaling, and will assess its potential for augmenting CAR-T cell activity. We will generate RASAL3 knockout CAR-TChimeric Antigen Receptor (CA...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2022 - 2024
    • •
  • 8 916 tis. Kč
    • •
  • 8 814 tis. Kč
    • •
  • GA ČR
Project

Topological regulation of CD4 and CD8 in T cells (GA19-07043S)

of early TCR signalling machinery in microvilli of resting T cells with highest cells. However, molecular mechanism how CD4, and to some extend CD8, modulate T cell and topology of T

Immunology

  • 2019 - 2022
    • •
  • 8 341 tis. Kč
    • •
  • 7 947 tis. Kč
    • •
  • GA ČR
Project

Role of virus-associated host-derived proteins in virus induced T cell dysfunction (GAP304/10/1161)

, are enveloped viruses, which infect CD4 T cells and cause transient (VZV) or progressive (SIV) dysregulation of T cell function. This effect is mainly indirect. This can be mediated by Akt-GSK3 pathway and PGE me...

EC - Imunologie

  • 2010 - 2016
    • •
  • 4 685 tis. Kč
    • •
  • 4 685 tis. Kč
    • •
  • GA ČR
Project

The role of Toll-like receptor signaling in the mechanism of central tolerance (GA19-23154S)

the selfreactive repertoire within the T cell population via deletion of T cells that express a self-reactive T cell antigen receptor or their deviation into regulatory T cells ...

Immunology

  • 2019 - 2021
    • •
  • 8 619 tis. Kč
    • •
  • 8 178 tis. Kč
    • •
  • GA ČR
Project

Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts (GA310/09/2084)

for spatial and temporal regulation of signaling events in T cells. T cell signaling leads of kinase active Lck to lipid rafts (LR). While this event is indispensable for T cell...

EC - Imunologie

  • 2009 - 2014
    • •
  • 6 750 tis. Kč
    • •
  • 6 750 tis. Kč
    • •
  • GA ČR
Project

Interplay of cytoskeleton and membrane morphology during formation of immunological synapse (GA23-06605S)

T-cells are key players in adaptive immunity. However, the critical events of T-cell activation and formation of IS. We will investigate how LFA-1 and CD2 actinin-1 and -4, control important aspects of T-<...

Immunology

  • 2023 - 2025
    • •
  • 9 956 tis. Kč
    • •
  • 9 956 tis. Kč
    • •
  • GA ČR
Project

Organisation and function of CD4 co-receptor on the surface of T cells at nanoscale (GA15-06989S)

of T cells. Different pools of CD4 molecules involved in TCR signallingCD4 glycoprotein functions as a co-receptor for the activation of T cells on resting and activated T cells at nanos...

EC - Imunologie

  • 2015 - 2019
    • •
  • 7 753 tis. Kč
    • •
  • 7 753 tis. Kč
    • •
  • GA ČR
Project

Identification of novel therapeutic and disease progression monitoring targets within surface, transcriptional and signaling programme of childhood T-cell acute lymphoblastic leukemia cells (NU23J-03-00026)

Acute leukemia is the most common pediatric malignancy. T-cell acute/refractory T-ALL, (e.g. daratumumab or anti-CD7 CAR T-cells) are under investigation antigens and signaling pathways is urgent....

Oncology

  • 2023 - 2026
    • •
  • 6 667 tis. Kč
    • •
  • 6 667 tis. Kč
    • •
  • MZ
Project

MICRORNA REGULATION OF B-T CELL INTERACTIONS IN THE AGGRESSIVENESS AND TRANSFORMATION OF “INDOLENT” B CELL MALIGNANCIES (NU22-03-00117)

signals. We hypothesize that are CLL/FL “aggressiveness” is driven by B cell-T cell is a key transcriptional mediator of malignant B cell-T cell interactions to STAT1 induction and incre...

Cell biology

  • 2022 - 2025
    • •
  • 12 881 tis. Kč
    • •
  • 12 881 tis. Kč
    • •
  • MZ
Project

T cell receptor signaling and fate decisions made by peripheral T cells in homeostasis and during inflammation (GJ16-09208Y)

Proper T cell fate choices are required for efficient immune responses as well as for maintaining self-tolerance. Incorrect T cell fate decisions may trigger allergy, autoimmunity, or immunodeficiency. T <...

EC - Imunologie

  • 2016 - 2018
    • •
  • 9 315 tis. Kč
    • •
  • 7 968 tis. Kč
    • •
  • GA ČR
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