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4 (0,117s)

Project

Trangenic and pharmacological complementation of inherited ATP synthase disorders (NV16-33018A)

are mutation in the gene for specific assembly factor TMEM70. Present therapy for mitochondrial diseases is rather limited and causal treatment is missing. However, TMEM70 is to (i) identify pharmacological activators of ATP synth...

FG - Pediatrie

  • 2016 - 2019
  • 14 567 tis. Kč
  • 14 567 tis. Kč
  • MZ
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

factor, the TMEM70, that is the first factor specific for higher eukaryotes. Its cellular models and generation of  TMEM70 conditional, tissue specific (Cre/LoxP......

CE - Biochemie

  • 2011 - 2015
  • 8 963 tis. Kč
  • 8 963 tis. Kč
  • GA ČR
Project

New factors regulating biogenesis of subunit c from mammalian FoF1 ATP synthase (GA20-25768S)

the mammalian enzyme, we have identified three proteins TMEM70, TMEM242 and c15orf61 to interact with subunit c. Of those, TMEM70 is already identified ATP synthase assembly......

Cell biology

  • 2020 - 2023
  • 6 786 tis. Kč
  • 6 786 tis. Kč
  • GA ČR
Project

Ketogenic diet as a treatment for inborn defects of ATP synthase (NU21-07-00550)

Mitochondrial disorders are among the most prevalent inborn errors of metabolism but largely lack treatments and have poor outcomes. ATP synthase deficiencies are primarily caused by mutations in specific assembly factor TMEM70, followed by ...

Biochemistry and molecular biology

  • 2021 - 2025
  • 9 665 tis. Kč
  • 9 665 tis. Kč
  • MZ
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