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79 (0,093s) •

Project

Relation between polymorphism of proinflamatory cytokine genes and male fertility (NR8064)

Aim of the project is exact definition of relation and predictive value of gene polymorphism of proinflamatory cytokines TNF-alfa, TNF-beta and TACE to male infertility.......

FK - Gynekologie a porodnictví

  • 2004 - 2006
    • •
  • 1 079 tis. Kč
    • •
  • 864 tis. Kč
    • •
  • MZ
Project

The interaction of cytokine TNF-alpha with butyrate during differentiation and apoptosis of color epithelial cells (GP524/02/P051)

that TNF-alpha inhibits differentiation and increases apoptosis induced by butyrate on moredetailedunderstanding of interactions between butyrate and TNF-alpha. Several cell lines derived to the alteration in cell sensitivity to

ED - Fyziologie

  • 2002 - 2004
    • •
  • 1 139 tis. Kč
    • •
  • 723 tis. Kč
    • •
  • GA ČR
Project

The importance of lectin-saccharide interactions of Eisenia foetida cytolytic factor CCF with ion channels for tumorilytic activity (GA310/02/1437)

exerts a large variety of TNF-like activities, particularly it lyses TNF-sensitive tumor cell lines. Since there is no sequential homology between TNF and CCF it can recently, interaction of TNF and CCF with Na+/K...

EC - Imunologie

  • 2002 - 2004
    • •
  • 3 254 tis. Kč
    • •
  • 1 575 tis. Kč
    • •
  • GA ČR
Project

Optimalization of diagnostic procedures in diabetic retinopathy (NK7730)

The image analysis and genotyping for polymorphisms in TNF-betaNcol, TGF beta and RAGE genes will be used to identify patients with future rapid onset and progression of diabetic retinopathy......

FF - ORL, oftalmologie, stomatologie

  • 2003 - 2005
    • •
  • 1 137 tis. Kč
    • •
  • 1 111 tis. Kč
    • •
  • MZ
Project

Dysregulation of signaling pathways in TNF-mediated autoimmunity (GA21-25251S)

Tumor necrosis factor (TNF) is a potent pro-inflammatory cytokine involved highly inflammatory cell death. Among major regulators of TNF-induced cell death is the kinase TBK1. In vitro data indicated that TBK1 recruitment to TNF...

Immunology

  • 2021 - 2023
    • •
  • 8 640 tis. Kč
    • •
  • 8 640 tis. Kč
    • •
  • GA ČR
Project

Soluble cytokine receptors - prognostic factor in breast cancer (NC6593)

The aim of the proposed study is to follow prospectively plasma levels of TNF, its soluble receptors and soluble IL-2 receptor in patients with newly diagnosed breast cancer and to correlate them with histologic grading. Clinical stage of th...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 2 719 tis. Kč
    • •
  • 2 686 tis. Kč
    • •
  • MZ
Project

The novel molecular biology methods in early diagnosis of acute and chronic rejection. Determination of gene expression within rejecting renal allografts. (NM7544)

Diagnosis of acute and chronic rejection of renal allograft using IL-6, IL-10, TNF-alpha, TGF-beta, RANTES, MCP-1 and CD3 gene expression (RT-PCR in real time) in kidney tissue. Observation of effect of polymorphisms in TNF-alpha, T...

FJ - Chirurgie včetně transplantologie

  • 2003 - 2005
    • •
  • 3 342 tis. Kč
    • •
  • 3 321 tis. Kč
    • •
  • MZ
Project

Supression of cytokines and possible management of initial phases of multi- organ failure in septic patients. (IZ2133)

9F - 9

  • 1994 - 1996
    • •
  • 204 tis. Kč
    • •
  • 323 tis. Kč
    • •
  • MZ
Project

The role of the changes of serum leptin, soluble leptin receptor and proinflammatory cytokines levels in the development of malnutrition of various etiology (NB6663)

(TNF-alpha, interleukin-1) in the etiology and development of anorexia...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 941 tis. Kč
    • •
  • 2 941 tis. Kč
    • •
  • MZ
Project

Cell adhesion and anoikis of intestinal cells - the role of TNF family members, AA metabolism, and differentiation (KJB500040508)

cells. Endogenous regulators from TNF family, which mediate apoptosis, can...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 1 161 tis. Kč
    • •
  • 1 161 tis. Kč
    • •
  • AV ČR
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