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151 (0,072s) •

Project

Relation between polymorphism of proinflamatory cytokine genes and male fertility (NR8064)

Aim of the project is exact definition of relation and predictive value of gene polymorphism of proinflamatory cytokines TNF-alfa, TNF-beta and TACE to male infertility.......

FK - Gynekologie a porodnictví

  • 2004 - 2006
    • •
  • 1 079 tis. Kč
    • •
  • 864 tis. Kč
    • •
  • MZ
Project

Detection of preclinical atherosclerosis in patients with rheumathoid arthritis and its management. (NK7374)

Association between endothelial function measured by ultrasoun in brachial aa. and inflammatory markes (C-reactive protein, orosomucoid, fibrinogen, intercellular adhesion molecule-1, and tumor necrosis factor alfa) in patients with rheumato...

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 1 218 tis. Kč
    • •
  • 1 173 tis. Kč
    • •
  • MZ
Project

The novel molecular biology methods in early diagnosis of acute and chronic rejection. Determination of gene expression within rejecting renal allografts. (NM7544)

transplantation and on gene expression in renal tissue. Observation of influence of TNF-alfaDiagnosis of acute and chronic rejection of renal allograft using IL-6, IL-10, TNF-alpha, TGF-beta, RANTES, MCP-1 and CD3 gene exp...

FJ - Chirurgie včetně transplantologie

  • 2003 - 2005
    • •
  • 3 342 tis. Kč
    • •
  • 3 321 tis. Kč
    • •
  • MZ
Project

Evaluation of possibility of medical use of Inerleukin 6 and Tumor necrosis factor alfa for acceleration of hypetrophy of liver parenchyma - animal model simulating conditions at patients after (NR8860)

On animal model we will ligate right sided branch of portal vein. Contemporary we will implant portal catheter. Through this way we will aplicate single dose of IL-6 or TNF-a or physiological solution. In the postoperative period we vein in ...

FJ - Chirurgie včetně transplantologie

  • 2006 - 2008
    • •
  • 2 308 tis. Kč
    • •
  • 2 308 tis. Kč
    • •
  • MZ
Project

Importance and time course of plasma metalloproteinases, solubile ligand CD40 and tissue factor in acute coronary syndrom (NR9176)

Proposed project anticipates assessment of time course of plasma level of circulating metalloproteinases -2, -9, PAPP-A, slCD40, TF, hsCRP, TNF-alfa, ASA-resistance in patients with acute coronary syndrome, and clinical follow-up of...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2009
    • •
  • 3 488 tis. Kč
    • •
  • 3 488 tis. Kč
    • •
  • MZ
Project

The role of genetic factors in susceptibility to alcoholic liver disease (NR8023)

The aim of the proposed study is to find combination(s) of genetic variants in 7 genes responsible for the genetic disposition to the development or serious course of ALD. Twelve polymorphisms in the 7 key genes will be analysed in min. 200 patients ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 647 tis. Kč
    • •
  • 1 557 tis. Kč
    • •
  • MZ
Project

The nature of acute and chronic humoral renal graft rejection at the level of molecular biology (NR9388)

To get to know pathophysiology of acute and chronic humoral rejection at the molecular level using analysis of intrarenal expression of TGF-ß1, TNF-alfa, RANTES,MC-1, HO-1, CD3, CD20 and IgJ genes. To assess the effect of upregulati...

FJ - Chirurgie včetně transplantologie

  • 2007 - 2009
    • •
  • 5 648 tis. Kč
    • •
  • 5 431 tis. Kč
    • •
  • MZ
Project

Laparoscopy treatment of organic hyperinsulinism. (NR8133)

Surgery is a radical treatment of organic hyperinsulinism. In our study we will investigate a tissue answer on surgical trauma (TNF-alfa, IL-1beta, IL-6, prokalcitonin, IL-2, IL-10), perioperative glucose balance and rate of postope...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 3 086 tis. Kč
    • •
  • 2 612 tis. Kč
    • •
  • MZ
Project

Predictive immunological markers in patients with hepatitis C viral infection (NT14072)

, IL-13, IFNg, TGF-b and TNF? and 4) Next imunological markers will be assessed with PegIFN alfa with RBV. 2) 20 pts that eliminated HCV infection without antiviral......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
    • •
  • 7 567 tis. Kč
    • •
  • 7 567 tis. Kč
    • •
  • MZ
Project

Glucose homeostasis disorders and pancreatic cancer new genetic and nutrition markers related to its occurrence and prognosis (NR9528)

In patients with pancreatic cancer (PC) we will study the polymorphisms -23Hpl (T/A) of the insulin gene promotor, selected adipokins (leptin, adiponectin, TNF-alfa), polyunsaturated fatty acids of plasma phospholipids and the gluco...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 6 286 tis. Kč
    • •
  • 6 064 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 151