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15 (0,124s) •

Project

Exploration of the TPP riboswitch as a new target for antibiotics (8F19007)

1. Explore the TPP riboswitch as a target for antibiotics, in particular for key ESKAPE pathogens and Streptococcus pneumoniae 2. Develop an HTS-compatible assay to monitor TPP riboswitch transcription regulation 3...

Microbiology

  • 2019 - 2023
    • •
  • 2 333 tis. Kč
    • •
  • 2 333 tis. Kč
    • •
  • MŠMT
Project

Mapping the conformational space of the riboswitches (GA18-25349S)

Riboswitches are regulatory elements mostly located in 5’-UTR region understanding of their regulatory mechanisms. While the most structures of riboswitches were of riboswitch actions. However, while coarse-grain methods ar...

Biophysics

  • 2018 - 2022
    • •
  • 3 409 tis. Kč
    • •
  • 2 872 tis. Kč
    • •
  • GA ČR
Project

Theoretical investigation of RNA structure, dynamics and function and their relationship. (ME09019)

(1) Finding new information about structure, dynamics and function of small RNA molecules (e.g. RNA aptamers, riboswitches) by applying methods of computational of free and bound form of riboswitches and the conformational changes c...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 1 660 tis. Kč
    • •
  • 1 660 tis. Kč
    • •
  • MŠMT
Project

Mitochondrial DNA manipulations for simulation of oxidative stress (KJB500110902)

The project will i) develop methods for nucleic acid import into the mitochondrial matrix of living cells such as HEPG2, HeLa, or INS1E cells, (using DNA-polyethylenimine conjugates with the mitochondrial addressing peptide (MAP) sequence; TPP

ED - Fyziologie

  • 2009 - 2011
    • •
  • 1 797 tis. Kč
    • •
  • 1 797 tis. Kč
    • •
  • AV ČR
Project

Social Rights of Temporary Protected Persons from Ukraine in the EU Countries the Evolution and Key Challenges of Further Development (GA25-18461S)

withsocial rights of TPPs as the most important group of rights for the majority and approaches to TPPs’ social protection in different EU countries, in particular those that have granted the TP to the biggest numbers of TPPs

Law

  • 2025 - 2027
    • •
  • 4 612 tis. Kč
    • •
  • 4 612 tis. Kč
    • •
  • GA ČR
Project

Mechanism of catalytical self-cleavage of two non-coding RNAs of human patogens (GPP301/11/P558)

of RNA underwent a revolution leading to discovery of other ribozymes, riboswitches pathogen ribozymes: Hepatitis delta virus ribozyme and glmS riboswitch from Bacillus......

FR - Farmakologie a lékárnická chemie

  • 2011 - 2013
    • •
  • 918 tis. Kč
    • •
  • 918 tis. Kč
    • •
  • GA ČR
Project

Experimental photodynamic therapy of tumore with employment of liposomal forms of novel photosenzitizers (NC6564)

Development and testing of liposomal forms of various photosenzitizers, eg.meso-tetrakis/phenylporphine (TPP), in order to obtain the highly efficient form for photodynamic therapy of tumors. The basic test will lie in the experimental photo...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 4 389 tis. Kč
    • •
  • 2 021 tis. Kč
    • •
  • MZ
Project

Mutation analysis in inherited metabolic neurodegenerative diseases with childhood onset (NR8351)

in eventual prenetal diagnosis. Biochemical analysis will be performed (TPP I activity...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 4 516 tis. Kč
    • •
  • 4 515 tis. Kč
    • •
  • MZ
Project

Biocomputational prediction of intergenic structures in Actinomyces (GA303/09/0475)

The proposed project is aimed at the biocomputational prediction and identification of functional intergenic structures as transcription terminators, small RNAs, riboswitches and antisense RNAs in the intergenic regions in Actinomyces genome...

CE - Biochemie

  • 2009 - 2011
    • •
  • 2 112 tis. Kč
    • •
  • 2 112 tis. Kč
    • •
  • GA ČR
Project

Use of lymphocyte mitochondria for detection and prospective analysis of mitochondrial diseases. (NT12370)

by cytofluorometric probe TMRM and by TPP+ electrode for analysis of energetic function...

FG - Pediatrie

  • 2011 - 2015
    • •
  • 8 773 tis. Kč
    • •
  • 8 773 tis. Kč
    • •
  • MZ
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