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14 (0,089s) •

Project

The role of TRPV1 receptors in nociceptive modulation (LH15279)

The aim of this project proposal is to study the role of TRPV1 receptors in modulation of synaptic transmission at the spinal cord level in pathological pain states. Modulatory mechanisms of TRPV1 receptors and interaction with TLR ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2017
    • •
  • 1 716 tis. Kč
    • •
  • 1 716 tis. Kč
    • •
  • MŠMT
Project

Structural and functional determinants on channels TRPC3, TRPV1, TRPV2 and TRPA1 (GA303/07/0915)

of N- and C - intracellular termini of channels TRPC3, TRPV1, TRPV2 and TRPA1, and onC- termini of TRPV1, to describe the binding sites for adaptor proteins like eferin or junctate on TRPV1, TRPV2 and TRPA1, the binding si...

CE - Biochemie

  • 2007 - 2009
    • •
  • 3 165 tis. Kč
    • •
  • 3 165 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction of C- and N- terminal segments of TRPV1 and TRPV3 channels with phospholipids. (GPP205/10/P308)

TRPV1 and TRPV3 channels are members of the TRP ion channel family. TRP channels are characterized by polymodal activation and its activity could be modulated, but the exact binding sites have not been determined in case of TRPV1 an...

BO - Biofyzika

  • 2010 - 2012
    • •
  • 1 218 tis. Kč
    • •
  • 1 218 tis. Kč
    • •
  • GA ČR
Project

CELLULAR AND MOLECULAR MECHANISMS OF PAIN TRANSMISSION AT SPINAL CORD LEVEL. (GA15-11138S)

of pathological pain states. The focus will be on the role of the vanilloid receptors (TRPV1 will be used. Elucidating the role of spinal TRPV1 receptors in nociceptive transmission......

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2017
    • •
  • 4 725 tis. Kč
    • •
  • 4 725 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of Neuropathic Pain States (LH12058)

of thiscooperation. The role of presynaptic TRPV1 receptors modulation on the endings of primary...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 3 546 tis. Kč
    • •
  • 3 382 tis. Kč
    • •
  • MŠMT
Project

Cellular and molecular mechanisms of pain transmission at spinal cord level. (GA305/09/1228)

of this project is to study the role of transient receptor potential vanilloid-1 (TRPV1...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 5 060 tis. Kč
    • •
  • 5 060 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular mechanisms of pain modulation at the spinal cord level (GA18-09853S)

of spinal transient receptor potential vanilloid receptors (TRPV1) and their interaction...

Neurosciences (including psychophysiology)

  • 2018 - 2020
    • •
  • 5 737 tis. Kč
    • •
  • 5 405 tis. Kč
    • •
  • GA ČR
Project

The role of cytokines and chemokines in the nociceptive signaling (GPP303/12/P510)

will be on presynaptic mechanism of cytokine TNFα and chemokine CCL2 modulation of TRPV1 hyperalgesia induced by CCL2 intrathecal application was blocked by TRPV1 receptor......

ED - Fyziologie

  • 2012 - 2014
    • •
  • 2 619 tis. Kč
    • •
  • 2 619 tis. Kč
    • •
  • GA ČR
Project

Neuroinflammation in development of pain (GA24-10712S)

Chronic painful conditions, especially of neuropathic origin are serious diseases that significantly limit patients by attacks of spontaneous pain and pain caused by innocuous stimuli. Current treatments are ineffective and with serious side effects....

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 6 987 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • GA ČR
Project

Molecular and Functional Characterization of Nociceptor-specific TRP Channels A Physiological Role in Acute and Chronic Pain (GA305/06/0319)

The ability of nociceptors to recognize noxious mechanical, chemical, and thermal stimuli is due to the specific activation of ionic channels expressed in peripheral endings of distinct primary afferents. The proposed project focuses on functional an...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 2 679 tis. Kč
    • •
  • 2 679 tis. Kč
    • •
  • GA ČR
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