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1 876 (0,14s) •

Project

New generation of preparations for amplifications of DNA fragments by polymerase chain reaction (1QS500520551)

search for more advantageous properties of mutagenized Taq DNA polymeraseAmplification of DNA fragments by polymerase chain reaction (PCR of complex PCR mixtures (containing DNA polymerases

EB - Genetika a molekulární biologie

  • 2005 - 2009
    • •
  • 4 077 tis. Kč
    • •
  • 3 735 tis. Kč
    • •
  • AV ČR
Project

Genetically modified polymerases and their use for amplification of unpurified DNA (FR-TI3/067)

of the project will be screening of Taq DNA polymerase mutants with new properties. ThesenewQuantitative real-time polymerase chain reaction (qPCR) is becoming a widely on amplification of DNA (or cDNA) f...

CE - Biochemie

  • 2011 - 2014
    • •
  • 5 600 tis. Kč
    • •
  • 4 400 tis. Kč
    • •
  • MPO
Project

New generations of DNA aptamers (TA01010436)

of temperature-resistant Taq DNA polymerase, for hot-start PCR, for identification of highlyThe aim of this project is to design new technologies for production of oligonucleotide DNA aptamers and to prepare D...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 13 690 tis. Kč
    • •
  • 10 900 tis. Kč
    • •
  • TA ČR
Project

Optimization of DNA segments amplification by polymerase chain reaction (IBS5052201)

PCR solutions containing PCR buffer, nucleotides, and DNA polymerase at optimalThe polymerase chain reaction (PCR) is a versatile method for rapid amplification of selected DNA segments. To further simplify PCR se...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 2 028 tis. Kč
    • •
  • 1 960 tis. Kč
    • •
  • AV ČR
Project

Translesion DNA synthesis across lesions induced by agents of biological significance. An insight into energetics, kinetics and mechanism (GA17-09436S)

of DNA due to its damage by DNA-damaging agents is an important factor dictating and controlling the processivity of translesion DNA polymerases. Structurally well-defined DNAThe biological effects of

BO - Biofyzika

  • 2017 - 2019
    • •
  • 5 627 tis. Kč
    • •
  • 5 006 tis. Kč
    • •
  • GA ČR
Project

DNA damage tolerance by plants (ME 535)

Sequence analysis of Arabidopsis genome revealed several homologues of DNA polymerases identified in bacteria and mammals that tolerate several kinds of DNA damage during replication. This finding support previous observati...

EB - Genetika a molekulární biologie

  • 2002 - 2003
    • •
  • 1 405 tis. Kč
    • •
  • 355 tis. Kč
    • •
  • MŠMT
Project

Modifications and bioorthogonal reactions in the major groove of DNA for regulation of protein binding and gene expression (GA14-04289S)

by DNA polymerases. The diverse types of modifications will be studied as protecting groups for regulation (switching) of binding of proteins to DNA. The influenceSynthesis of novel base-modified oligonucleotides (ONs) and...

CE - Biochemie

  • 2014 - 2016
    • •
  • 9 994 tis. Kč
    • •
  • 9 994 tis. Kč
    • •
  • GA ČR
Project

Novel anti-Stokes lanthanide nanoparticles and multicolor FRET mechanisms for single-molecule DNA sequencing (GF23-06199K)

) that have a genetic component. Although a few DNA sequencing methods exist, detecting the activity of a single DNA polymerase molecule by fluorescence microscopy) system in combination with single DNA polymer...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2023 - 2025
    • •
  • 6 525 tis. Kč
    • •
  • 6 525 tis. Kč
    • •
  • GA ČR
Project

Artificial epigenetics Development of a eukaryotic bioorthogonal transcription system for gene expression manipulation in the cell. (GA17-03419S)

Natural DNA modifications are epigenetic signals that are vital for regulation of gene expression. Artificial DNA modifications possess immense potential with respect to modulate the way how RNA polymerase (the key enzyme o...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 537 tis. Kč
    • •
  • 9 072 tis. Kč
    • •
  • GA ČR
Project

Novel Functionalized (Bio)polymers Based on DNA Display of Small Molecules (GX20-00885X)

The project aims at development of chemical and enzymatic synthesis of sequence-specific hyper-functionalized monodispersed polymers based on DNA or RNA scaffold containing all 4 (or even 6) modified bases. We will design and synthesize the ...

Organic chemistry

  • 2020 - 2024
    • •
  • 45 858 tis. Kč
    • •
  • 44 830 tis. Kč
    • •
  • GA ČR
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