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5 270 (0,146s) •

Project

Synthetic biodegradable polymeric systems for targeted gene delivery (KJB400500803)

The project focuses on the synthesis of new biodegradable gene delivery vectors (DNA) from degradation in blood circulation and release it in the target tissue (cell). The project consist of two main parts: i) Design and synthes...

CD - Makromolekulární chemie

  • 2008 - 2009
    • •
  • 638 tis. Kč
    • •
  • 638 tis. Kč
    • •
  • AV ČR
Project

New Enzymes and Selective Methods for Glycosidase-Catalysed Synthesis of Bioactive Glycosides and Glycomimetics (OC D25.002)

New enzymes for synthesis of oligoglycosides will be screened and characterized will be created. Novel methods for enzymatic synthesis of bioactive glycosides, ill be used as targets for enzymatic glycosylation.New syntheti...

CE - Biochemie

  • 2002 - 2006
    • •
  • 2 636 tis. Kč
    • •
  • 1 726 tis. Kč
    • •
  • MŠMT
Project

Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells (GA15-15264S)

The project is focused on the synthesis and study of biological effects of some acid. These conjugates are perspective candidates for targeted transport receptors), which are overexpressed in a large number of cancers. The targe...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 4 631 tis. Kč
    • •
  • 4 631 tis. Kč
    • •
  • GA ČR
Project

Study and preparation of (18F) Fluorothymidene, pharmacokinetic properties verification using PET (IBS1048352)

Completion of studies of 2.2 ml target for the irradiation of (18O) enriched water (18O) H2O. The observation of yield after target irradiation and observation of possible traces of impurities presented in irradiated target...

CH - Jaderná a kvantová chemie, fotochemie

  • 2003 - 2005
    • •
  • 5 749 tis. Kč
    • •
  • 5 749 tis. Kč
    • •
  • AV ČR
Project

*Targeted supercancerostatics of new generation for leucemia therapy. (FT-TA2/081)

*Technology of specific ligands production development targeted for complexation of radionuclides. Ligands will be content reactive functional groups for conjugation with monoclonal antibody antiCD66. The conjugate will be applied in leucemi...

CC - Organická chemie

  • 2005 - 2008
    • •
  • 70 398 tis. Kč
    • •
  • 48 451 tis. Kč
    • •
  • MPO
Project

Steroid neuronal signal and ion flux modulators (NEURION) (GA203/97/0695)

for both the development of organic synthesis with the aim of the broadening and morphology. The synthesis of preselected models of monounit steroidal heterocycles across the biological and synthetic membranes are typical challengi...

CC - Organická chemie

  • 1997 - 1999
    • •
  • 2 489 tis. Kč
    • •
  • 1 656 tis. Kč
    • •
  • GA ČR
Project

Center of targeted therapeutic drugs (1M0505)

as targets for anti-tumour therapy. Elaboration of technology of preparation methods of the produced recombinant antibodies. To propose structures, synthesis to their effect. Development and synthesis of new anti-tumour dr...

EI - Biotechnologie a bionika

  • 2005 - 2011
    • •
  • 225 617 tis. Kč
    • •
  • 200 673 tis. Kč
    • •
  • MŠMT
Project

Synthesis and biological activity studies of 6-(fluoroalkyl)- and 6-(fluoroalkenyl)purine derivatives (GA203/98/P027)

The subject of this grant application is the synthesis and biological activity studies of 6-(fluoroalkyl)- and 6-(fluoroalkenyl)- derivatives of purine bases, nucleosides, nucleotides and their acyclic analogues. A key step in their synt...

CE - Biochemie

  • 1998 - 1999
    • •
  • 1 233 tis. Kč
    • •
  • 382 tis. Kč
    • •
  • GA ČR
Project

Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains (NT13346)

This is an interdisciplinary applied research, aimed at suppressing extensively growing mycobacterial infections, including resistant and multidrug resistant strains. The project is based on a molecular modelling (in silico), synthesis of ne...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 8 054 tis. Kč
    • •
  • 8 054 tis. Kč
    • •
  • MZ
Project

Utilization of speech synthesis to improve teaching of foreign languages (EG15_019/0004982)

The project deals with the research of the use of computer speech synthesis to improve the quality of foreign language teaching and the development of teaching systems using speech synthesis technology. The main objective is to inte...

IN - Informatika

  • 2015 - 2020
    • •
  • 7 918 tis. Kč
    • •
  • 1 306 tis. Kč
    • •
  • MPO
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