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1 398 (0,121s) •

Project

Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine (NS9871)

This study aims to prepare a clinical grade cancer vaccine based on optimized dendritic cells loaded with tumor associated antigens tailored for each individual patient.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 171 tis. Kč
    • •
  • 8 171 tis. Kč
    • •
  • MZ
Project

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

using dendritic cells loaded with different myeloma antigens. Irradiated myeloma cells, myeloma mRNA or peptides derived from tumor associated proteins will be used as tumor antigens. This approach will lead to th...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Project

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

it was evaluated as a promising target antigen for immunotherapy of tumors. WT1 geneWT1 gene is highly expressed in myeloid leukemia and in some solid tumors expression, which could increase sensitivity of tumor c...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
    • •
  • 10 317 tis. Kč
    • •
  • MZ
Project

Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity (NR9246)

Enhancement of efficacy of therapeutic anti-tumor vaccines based on fusion of a tumor antigen with E. coli beta-glucuronidase. Increase of production of immunogens of a tumor antigen.. of immunization effe...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 294 tis. Kč
    • •
  • 8 104 tis. Kč
    • •
  • MZ
Project

Molecules Associated with Carcinoembryonic Antigen in Normal and Tumor Tissues (GA301/93/0323)

9H - 9

  • 1993 - 1995
    • •
  • 612 tis. Kč
    • •
  • 1 224 tis. Kč
    • •
  • GA ČR
Project

Generation of dendritic cells in vitro, their characteristics, antigen presenting capacity and potential use in the immunotherapy of minimal residual disease in (NI5669)

Monocyte-derived dendritic cells cultivated in vitro will be pulsed with tumor antigens and cocultivated with autologous lymphocytes in vitro to gain efficient cytotoxic cells directed against tumor cells. The project is fo...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 1 362 tis. Kč
    • •
  • 1 362 tis. Kč
    • •
  • MZ
Project

Significance of special diagnostic methods for the differentiated therapy of pre-tumorous and tumorous brest affections. (IZ2319)

9F - 9

  • 1994 - 1996
    • •
  • 611 tis. Kč
    • •
  • 893 tis. Kč
    • •
  • MZ
Project

Knowledge deepening on immunology of chronic myeloid leukemia necessary precondition of future terapeutic vaccine (NT12363)

of 15-20 selected antigens, determination of the cellular and humoral immunity to these antigens, and correlation of the findings with the clinical picture. An attempt to determine the optimal time for administering the anti-tu...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 10 493 tis. Kč
    • •
  • 9 457 tis. Kč
    • •
  • MZ
Project

Density of CD20 and CD52 antigens expression on tumor cells in patients with tumors of lymphoid origin in relation to monoclonal antibody treatment (NR9023)

and CD52 in MESF units on the tumor cells of lymphomas and leukemias with quantitative multiparametric flow cytometry. CD20 and CD52 expression on tumor cells and normal lymphocytes residual disease and antigen density aft...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 1 527 tis. Kč
    • •
  • 1 400 tis. Kč
    • •
  • MZ
Project

Determination of tumor mRNA in patients with colorectal carcinoma as a screening and prognostic method using reverse-transcriptase polymerase chain reaction RT-PCR and comparison with traditional (NR7894)

the method sensitivity to postoperative recurrence and tumor disease metastases with determination of usual tumor markers - carcinoembrional antigen CEA, antigen Ca 19-9To determine a level of tumor mRNA ...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 1 743 tis. Kč
    • •
  • 1 729 tis. Kč
    • •
  • MZ
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