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3 648 (0,114s) •

Project

Discovery and development of novel tumor-suppressor-based reactivation cancer therapies (NW25-03-00073)

and complete loss of tumor suppressor genes/proteins in cancer cells. However, in the case of haploinsufficient/dose-dependent tumor suppressors, such as LACTB, where the tumor suppressor

Oncology

  • 2025 - 2028
    • •
  • 19 501 tis. Kč
    • •
  • 18 255 tis. Kč
    • •
  • MZ
Project

Amplification of mycooncogenes and deletion of some suppressor genes in lung tumors. (IZ2291)

FD - Onkologie a hematologie

  • 1994 - 1997
    • •
  • 1 555 tis. Kč
    • •
  • 2 040 tis. Kč
    • •
  • MZ
Project

HMGB1 role in modulation of tumor suppressors and telomere integrity (GA204/05/2031)

p53 is a crucial tumor suppressor for preventing malignant transformation, but by the tumor suppressor retinoblastoma protein Rb. Previously we háve reported including DNA replication, recombination, transcription,...

CE - Biochemie

  • 2005 - 2007
    • •
  • 3 528 tis. Kč
    • •
  • 3 528 tis. Kč
    • •
  • GA ČR
Project

Interactions of p53 family proteins with biologically significant DNA quadruplexes (GA13-36108S)

Tumor suppressor function of p53, p63 and p73 proteins is strongly dependent and map of tumor suppressor p53 family member’s interactions with G-quadruplexes of selected genes (e.g. VEGF, hTERT, c-myc, EGR...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 4 919 tis. Kč
    • •
  • 4 919 tis. Kč
    • •
  • GA ČR
Project

Study of molecular mechanisms affecting phosphatase activity of PTEN gene product (GA204/01/0488)

The PTEN is recently discovered tumor suppressor gene like p53, pRB etc., with a phosphatase activity and sequence similarity to some cytoskeletal proteins. The alterations of the PTEN were found in advanced stages of numer...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 859 tis. Kč
    • •
  • 1 859 tis. Kč
    • •
  • GA ČR
Project

Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (OC10042)

epigenetic alterations of tumor suppressor genes, genes involved in differentiation, apoptosis, metastasis etc. The alterations of gene promoter methylation lead will examine the DNA methylation status of...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 2 400 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MŠMT
Project

Determination of functional status of tumor suppressor p53 in acute myeloid leukemia by using of method FASAY. (NC6395)

The project concentrates on determination of functional status of tumor suppressor p53 in cells of patients with acute myeloid leukemia by functional method called FASAY,which is based on measuring of transactivation ability of p53 ...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 383 tis. Kč
    • •
  • 3 383 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas (NR9305)

The aim of this project is complex analysis of tumor suppressor p53 in tumor tissue of patients with diffuse large B-cell lymphoma and mantle cell lymphoma to verify whether p53 abberation is useful prognostic marker of the...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 494 tis. Kč
    • •
  • 2 494 tis. Kč
    • •
  • MZ
Project

Interactions of mutant p53 with genomic DNA in vitro and in vivo (1K04119)

The tumor suppressor gene p53 belongs to the most frequently mutated genes in human cancer. This proposal is focused on elucidation of the impacts of specific mutp53 DNA binding activity in its "gain of function" e...

EB - Genetika a molekulární biologie

  • 2004 - 2007
    • •
  • 2 672 tis. Kč
    • •
  • 2 420 tis. Kč
    • •
  • MŠMT
Project

Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells (NS10448)

We propose to perform detailed analysis of 23 temperature-dependent mutants of the p53 tumor suppressor in H1299 human cells to determine the level of temperature-dependency, discriminative character and susceptibility to reactivati...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 3 140 tis. Kč
    • •
  • 3 140 tis. Kč
    • •
  • MZ
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