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2 852 (0,08s) •

Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemi...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

The role of beta-arrestin in achieving Wnt-signaling specificity (GC204/09/J030)

-canonical Wnt-pathways. A number of new variations of Wnt-signaling, especially of the individual branches of Wnt signaling. To test this hypothesis, we will characterize the molecular function a...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 3 888 tis. Kč
    • •
  • 3 888 tis. Kč
    • •
  • GA ČR
Project

Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling (GA204/09/0498)

Mutations in the Wnt signalling pathway cause several human diseases including (Dvl) ? a key component of the Wnt signalling pathway. We plan to describe with respect (i) to the Wnt p...

CE - Biochemie

  • 2009 - 2013
    • •
  • 6 895 tis. Kč
    • •
  • 6 895 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressors in the Wnt signaling pathway (GA204/07/1567)

Wnt signaling controls embryonic development and the aberrant activation of the Wnt pathway leads to cancer. In canonical signaling beta-catenin acts with the TCF/LEF factors to transduce the signal

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 433 tis. Kč
    • •
  • 4 433 tis. Kč
    • •
  • GA ČR
Project

Molecular cloning and functional characterization of the Wnt signaling pathway components in man (IAA5052905)

Wnt proteins are secreted signaling molecules that regulate diverse developmental processes. The Wnt action is mediated via a signal transducing cascade of the opithelial cells, hasbeen observed in human colon carc...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 2 936 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • AV ČR
Project

The role of phosphoinositides in Wnt signalling (GJ16-17966Y)

The Wnt signalling pathway is essential for many events during human the importance of PIP metabolism in Wnt pathway control. To elaborate on these findings, we in the regulation of Wnt signal...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

The role of Wnt/beta-catenin signaling during neurogenesis. (GA17-05466S)

Wnt signaling plays an essential role in the development of mammalian CNS. We will investigate the impact of the canonical Wnt pathway both on neuronal/glial differentiation or the Wnt inhibitor Dkk1. Furt...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 5 720 tis. Kč
    • •
  • 5 556 tis. Kč
    • •
  • GA ČR
Project

Characterization of early stages of intestinal tumorigenesis induced by non-physiological activation of Wnt signaling (GA20-31322S)

The Wnt signaling pathway regulates a number of biological processes during embryonic development and in adult tissues. Dysfunction of Wnt signaling initiates of Wnt pathway inhibitor, tu...

Cell biology

  • 2020 - 2022
    • •
  • 8 985 tis. Kč
    • •
  • 8 985 tis. Kč
    • •
  • GA ČR
Project

Study of the functions of endocytosis and intracellular trafficking regulators in Wnt signalling (GAP305/10/0507)

The Wnt signalling pathway is required during a wide variety of developmental pathways have emerged as important regulators of Wnt signalling. However, an in-depth and cell fate specification. Der...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 4 083 tis. Kč
    • •
  • 4 083 tis. Kč
    • •
  • GA ČR
Project

Posttranslational modification of Dishevelled (KJB501630801)

and regeneration. Mutations in the Wnt pathway are crucial in pathogenesis of many diseases signalling pathways. The immediate downstream component necessary for transduction of all branches of Wnt si...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 290 tis. Kč
    • •
  • 1 290 tis. Kč
    • •
  • AV ČR
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