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319 (0,241s) •

Project

The study of interactions among IgA1-glycosylating enzymes in IgA nephropathy (LH11046)

Abnormalities in immunoglobulin A1 (IgA1) O-linked glycosylation belong distribution contribute significantly to abnormal IgA1 O-glycosylation. The first aim ST6GalNAcII, C1GalT1, C1GalT2, and GalNAcT2 contribute i...

EC - Imunologie

  • 2011 - 2014
    • •
  • 1 822 tis. Kč
    • •
  • 1 822 tis. Kč
    • •
  • MŠMT
Project

Towards a new era for the identification and characterisation of inborn errors of glycosylation (8F19002)

1.Combine omics approaches to solve the most elusive unsolved CDG cases; 2.Develop new ‘omics’ biomarkers for the detection, elucidation and prognosis of the disease; 3.Promote research into the pathophysiology of the disease; 4.Exploit new hypothese...

Social biomedical sciences (includes family planning, sexual health, psycho-oncology, political and social effects of biomedical research)

  • 2019 - 2022
    • •
  • 3 843 tis. Kč
    • •
  • 3 843 tis. Kč
    • •
  • MŠMT
Project

Regulation of NMDA receptor trafficking and function by N-glycosylation (GA14-02219S)

that the abnormal regulation of NMDA receptors underlies a wide variety of neurological receptors are N-glycosylated, the effect of this modification on the regulation of NMDA, electrophysiology to elucidate i) if the N-glycosy...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2016
    • •
  • 5 123 tis. Kč
    • •
  • 5 123 tis. Kč
    • •
  • GA ČR
Project

Study of IgA1 glycosylation in IgA nephropathy (GAP302/10/1055)

polymeric IgA1 with aberrantly glycosylated, galactose-deficient, hinge-region O-linked of involved enzymes; 2) abnormal distribution of enzymes in the Golgi apparatus where O-glycosylation takes place; 3) competition betw...

EC - Imunologie

  • 2010 - 2013
    • •
  • 4 882 tis. Kč
    • •
  • 4 882 tis. Kč
    • •
  • GA ČR
Project

The role of glycosylation in regulation of cytokinin levels and control of morphogenic responses of selected crop plants (GA522/99/1130)

metabolism is glycosylation, which considerably influences the level of physiologically active cytokinins in plant cells. Glycosylation can be either reversible (O- or N3-glycosylation resulting in storage forms of cytokin...

GE - Šlechtění rostlin

  • 1999 - 2001
    • •
  • 2 267 tis. Kč
    • •
  • 1 660 tis. Kč
    • •
  • GA ČR
Project

The use of surface glycosylation in the immune recognition and elimination of tumors (GA204/06/0771)

carcinoma and melanoma in vivo relate to the changes in surface tumor glycosylation glycosylation of the cell lines relevant to the above tumor models related to different; (b), to describe better the changes in tumor cell surface ...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 2 940 tis. Kč
    • •
  • 2 940 tis. Kč
    • •
  • GA ČR
Project

Novel Biocatalysts for the Production of Glycosides (7E11011)

of glycosides (NOVOSIDES). Glycosylated compounds have a wide range of applications, but very few enzymes are able to glycosylate small organic molecules cost-efficiently at the industrial scale. Therefore, glycosylation r...

CE - Biochemie

  • 2011 - 2014
    • •
  • 3 659 tis. Kč
    • •
  • 3 659 tis. Kč
    • •
  • MŠMT
Project

Stereodirecting effects of deoxofluorination at C-3 and C-4 of 2-azido-2-deoxy-hexopyranosyl donors (GA17-18203S)

of glycosylation is increasingly recognized. We propose to study how fluorine substituents in glycosylation of a series of glycosyl acceptors. The fluorinated thioglycoside procedures for alfa-selective glycosylation

CC - Organická chemie

  • 2017 - 2021
    • •
  • 5 324 tis. Kč
    • •
  • 4 664 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of congenital disorders of glycosylation (NV16-31932A)

Congenital Disorders of Glycosylation (CDG) represents a large group of severe inherited metabolic diseases that are caused by impaired biosynthesis of glycoproteins and glycolipids.The complexity of glycosylation pathways determine...

CE - Biochemie

  • 2016 - 2020
    • •
  • 11 463 tis. Kč
    • •
  • 11 435 tis. Kč
    • •
  • MZ
Project

The study of the bases of congenital disorders of glycosylation (NT12166)

Congenital disorders of glycosylation (CDG) represent a heterogeneous group of metabolic disorders caused by > 40 types of defects in biosynthesis of N- and O ApoCIII for the determination of O-glycosylation defects will be establis...

FG - Pediatrie

  • 2011 - 2015
    • •
  • 7 989 tis. Kč
    • •
  • 7 989 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 319