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55 (0,061s) •

Project

Modulation of structural and functional properties of the HSP90 chaperone machinery by reversible acetylation (GA21-31806S)

, including lysine acetylation. Biological data suggest that histone deacetylase 6 (HDAC6)acetylation by HDAC6 and functional consequences of such interactions have not been acetylation. Specifically, we will purify ace...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 9 135 tis. Kč
    • •
  • 9 135 tis. Kč
    • •
  • GA ČR
Project

Nuclear Structure and Histone Acetylation in Plant Cells (IAA5004901)

active gene regions. Using antisera directed against acetylated isoforms of H4 and H3 andindirect immunocytochemistry we will analyse histone acetylation patterns development. Histone acetylation status will be studied and...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 4 366 tis. Kč
    • •
  • 2 079 tis. Kč
    • •
  • AV ČR
Project

The efect of methylation and acetylation on chromatin structure (GP202/03/D033)

Biochemical modifications of DNA and histones (especially methylation and acetylation) belong to mechanisms of epigenetic regulation which influence chromatin the acetylation status of histones on metaphase chromosomes of humid bloo...

EB - Genetika a molekulární biologie

  • 2003 - 2006
    • •
  • 736 tis. Kč
    • •
  • 736 tis. Kč
    • •
  • GA ČR
Project

Synthesis of sirtuin inhibitors (LD14128)

The aim of this project is to synthesize sirtuin inhibitors, structurally related to the product of their enzymatic reaction, acetylated adenosine diphosphoribose. These inhibitors will have the acetyl functionality of mother molecu...

CC - Organická chemie

  • 2014 - 2016
    • •
  • 1 462 tis. Kč
    • •
  • 1 462 tis. Kč
    • •
  • MŠMT
Project

The ways to N-acetyl-mannosamine structures via mannoside metabolizing enzymes (GAP207/10/0321)

N-Acetyl-D-mannosamine (ManNAc), and some ManNAc-containing saccharides (e.g., GlcNAc-?-(1-4)ManNAc) were found to be strong immunostimulants. A series of chemical syntheses of ManNAc-containing compounds were recently published, but these s...

CE - Biochemie

  • 2010 - 2013
    • •
  • 4 793 tis. Kč
    • •
  • 4 793 tis. Kč
    • •
  • GA ČR
Project

Regulation of alternative splicing via chromatin acetylation (GAP305/10/0424)

a novel mechanism of splicing regulation via chromatin acetylation. Our substantial pursue an alternative hypothesis assuming that chromatin acetylation change speed......

EB - Genetika a molekulární biologie

  • 2010 - 2013
    • •
  • 4 813 tis. Kč
    • •
  • 4 813 tis. Kč
    • •
  • GA ČR
Project

Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine (OVUOFVZ200806)

To evaluate whether the bioindicators of oxidative and nitrative stress and inflammations of the airways can be used as biodosimetric markers after exposure to gamma radiation, after whole-body and partial irradiation of rats. To evaluate protective ...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 955 tis. Kč
    • •
  • 3 249 tis. Kč
    • •
  • MO
Project

Study of the chromatin changes during plant microsporogenesis and microgametogenesis (GA521/98/P061)

Project is based on the recent knowledge concerning the role of DNA methylation and histone acetylation in control of the chromatin structure formation and gene acetylation are stable in the generative nucleus, the vegetative nucleu...

GE - Šlechtění rostlin

  • 1998 - 2000
    • •
  • 737 tis. Kč
    • •
  • 675 tis. Kč
    • •
  • GA ČR
Project

Structural characterization of NuA4 with a nonhistone acetylation target (8J25FR006)

for binding other proteins to acetylate is the same or partially different and what preparation of a non-histone acetylation target, 2) isolation of the endogenous NuA4 enzyme complex, 3) verification of enzymatic activity by a...

Biochemistry and molecular biology

  • 2025 - 2026
    • •
  • 157 tis. Kč
    • •
  • 157 tis. Kč
    • •
  • MŠMT
Project

The reasbons for dekompensation of health status of the geriatric patients (IZ4330)

FE - Ostatní obory vnitřního lékařství

  • 1997 - 1998
    • •
  • 344 tis. Kč
    • •
  • 344 tis. Kč
    • •
  • MZ
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