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Projects

39 projects (0,089s) •

Project

New purine nucleoside analogues for therapeutic applications (OC D13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

CC - Organická chemie

  • 2001 - 2003
    • •
  • 2 662 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • MŠMT
Project

New purine nucleoside analogues for therapeutic applications (1P04OCD13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 891 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

Immunobiological Activity of Acyclic Nucleotide Analogues (GA307/94/0964)

FR - Farmakologie a lékárnická chemie

  • 1994 - 1996
    • •
  • 1 377 tis. Kč
    • •
  • 2 047 tis. Kč
    • •
  • GA ČR
Project

Novel Cytostatics Based on Acyclic Nucleotide Analogg (GA203/93/0117)

CE - Biochemie

  • 1993 - 1995
    • •
  • 355 tis. Kč
    • •
  • 710 tis. Kč
    • •
  • GA ČR
Project

Novel cytostatics based on acyclic nucleotide analogs Mode of action (IAA455402)

9J - 9

  • 1994 - 1996
    • •
  • 441 tis. Kč
    • •
  • 679 tis. Kč
    • •
  • AV ČR
Project

Acyclic Analogues of Nicotinamide Mononucleotide and Nicotinamide Adenine Dinucleotide as Potential Cytostatics and Antivirals (GA203/93/0118)

9J - 9

  • 1993 - 1995
    • •
  • 700 tis. Kč
    • •
  • 1 400 tis. Kč
    • •
  • GA ČR
Project

Synthesis of base and chein-modified phosphonate analogues of acyclic nucleotides and nicotinamide adenine dinucleotide (IAA455407)

9J - 9

  • 1994 - 1996
    • •
  • 512 tis. Kč
    • •
  • 791 tis. Kč
    • •
  • AV ČR
Project

Synthesis and biological activity study of acyclic adenosine analogues with alfa-branched side chain (GA203/98/P026)

A series of acyclic adenosine analogues with a-branched side chain bearing various functional groups was studied. A new method based on the derivatization of N6-protected adenine derivatives bearing an active methylene group in N7- or N9-pos...

CE - Biochemie

  • 1998 - 1998
    • •
  • 677 tis. Kč
    • •
  • 201 tis. Kč
    • •
  • GA ČR
Project

Syntheses of new prodrug forms of biologically active nucleotide analogues (GA14-00522S)

acyclic nucleoside phosphonates thus far not clinically developed potential of acyclic nucleoside phosphonates as antitumor agents.......

CC - Organická chemie

  • 2014 - 2016
    • •
  • 4 481 tis. Kč
    • •
  • 4 481 tis. Kč
    • •
  • GA ČR
Project

Novel types of acyclic nucleoside phosphonates with potential antimalarial activity hypoxanthine-guanine-xanthine phosphoribosyltransferase inhibitors (GAP207/11/0108)

Recently, some acyclic nucleoside phosphonates (ANPs) were recognized as in vitro inhibitors of the key enzyme of purine salvage pathway hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT). The malarial parasite Plasmodium falci...

CC - Organická chemie

  • 2011 - 2014
    • •
  • 7 432 tis. Kč
    • •
  • 7 432 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 39