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3 014 (0,117s) •

Project

Signaling and adaptor proteins of leukocyte membrane microdomains (GEMEM/09/E011)

Biochemical and functional characterization of several novel adaptor proteins transmembrane adaptors. Elucidation of protein-lipid interactions and protein motifs and preliminaryexperimental results).2)   ...

EC - Imunologie

  • 2009 - 2012
    • •
  • 6 633 tis. Kč
    • •
  • 6 633 tis. Kč
    • •
  • GA ČR
Project

Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells (GAP302/10/1759)

and cytoplasmic components to produce unique signalosomes around transmembrane adaptor proteins. To this aim we will use strains of mice deficient in the expression of various adaptor proteins, and compare detaile...

EC - Imunologie

  • 2010 - 2013
    • •
  • 4 998 tis. Kč
    • •
  • 4 998 tis. Kč
    • •
  • GA ČR
Project

DNA Display of Ligands or Reactive Groups for Multivalent Spatial Recognition, Recruitment and Arrangement of Proteins (GA25-15592S)

of RNA. Fusion proteins containing the target protein and adaptor will be designedThe aim of the project is to develop a generic platform for display of proteins of proteins will be synthesized and used i...

Organic chemistry

  • 2025 - 2027
    • •
  • 12 165 tis. Kč
    • •
  • 11 487 tis. Kč
    • •
  • GA ČR
Project

Center of Molecular and Cellular Immunology (1M0506)

Elucidate immune functions of selected signaling molecules(adaptor proteins PAG, NTAL, LIME, nonreceptor protein-tyrosine and lipid phosphatases) and defects of their functions in some diseases. Identify, clone and function...

EC - Imunologie

  • 2005 - 2011
    • •
  • 242 918 tis. Kč
    • •
  • 215 618 tis. Kč
    • •
  • MŠMT
Project

Mediated endocytosis of host hemoglobin in tick gut cells (GPP502/11/P682)

hemoglobin. A priority is the identification of the receptor and clathrin adaptor protein by ultrastructural studies and different endocytic pathways for serum proteins and hemoglobin by reverse genetic approach (expressio...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 490 tis. Kč
    • •
  • 2 490 tis. Kč
    • •
  • GA ČR
Project

New target genes for childhood leukemia diagnosis and treatment focused on adaptor molecules of signaling pathways (2B06064)

. Selected candidate proteins must be confirmed with respect to their proper expression and localization within cells. Since the adaptor proteins of signaling pathways are central posttranslational modifications. This ultim...

FD - Onkologie a hematologie

  • 2006 - 2011
    • •
  • 29 140 tis. Kč
    • •
  • 25 820 tis. Kč
    • •
  • MŠMT
Project

Analysis of the role of transmembrane adaptor protein OPAL1 in the regulation of leukocyte receptor signaling with focus on chemokine receptor CXCR4 (GA16-07425S)

transmembrane adaptor protein OPAL1. Until now OPAL1 has been known only at mRNA level as a leukemia marker. We now show that OPAL1 is an adaptor for NEDD4-family E3 ubiquitin......

EC - Imunologie

  • 2016 - 2020
    • •
  • 7 917 tis. Kč
    • •
  • 7 134 tis. Kč
    • •
  • GA ČR
Project

The role of interactions of adaptor protein PSTPIP2 in the development of autoinflammatory disease (GA19-05076S)

Mouse strains, in which deficiency in adaptor protein PSTPIP2 results in autoinflammatory osteomyelitis belong among the best-studied models of autoinflammatory diseases. Osteomyelitis in these mice is caused by hyperproduction of p...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 121 tis. Kč
    • •
  • 7 593 tis. Kč
    • •
  • GA ČR
Project

The regulatory role of NTAL in receptor-mediated signaling in mast cells (GA301/06/0361)

Aggregation of the high-affinity IgE receptor (FceRI) leads to tyrosine phosphorylation of numerous substrates including the adaptor protein LAT. Recently, we identified in mast cells a new adaptor protein NTAL, wh...

EC - Imunologie

  • 2006 - 2008
    • •
  • 4 831 tis. Kč
    • •
  • 4 831 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of the regulation of hematopoiesis and immune response by transmembrane adaptor protein WBP1L (GA21-25527S)

regulated by this protein. The results of this project will help us better understand...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 8 229 tis. Kč
    • •
  • 8 103 tis. Kč
    • •
  • GA ČR
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