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65 (0,16s) •

Project

Degradation products of protein adducts in urine as a new type of biomarkers in toxicology (NT13401)

Although the adducts with blood protein globin are known biomarkers of long degradation of adducted globin will liberate amino acid adducts, which will be partly biomarkers. To address this hypothesis, a series of model ami...

CE - Biochemie

  • 2012 - 2015
    • •
  • 7 227 tis. Kč
    • •
  • 7 036 tis. Kč
    • •
  • MZ
Project

Characterisation of covalent adducts of relevant industrial xenobiotics with human globin (GA303/00/0923)

with biological macromolecules ( proteins, DNA) covalent adducts, which may cause adverse a number of procedures for determination of specific adducts with blood proteins in protein primary structure, adduct stechiometry, ...

CE - Biochemie

  • 2000 - 2002
    • •
  • 4 770 tis. Kč
    • •
  • 1 744 tis. Kč
    • •
  • GA ČR
Project

Molecular dosimetry of the exposure to alkylating agents. Determination of the adducts with globin using modified Edman degradation procedure. (NJ7387)

Specific analytical procedures for determination of alkyl adducts of alkylating agents with N-terminal valine of globin will be implemented and validated. Purpose: Improvement of biological monitoring of exposure to industrial toxicants.......

FM - Hygiena

  • 2003 - 2005
    • •
  • 2 995 tis. Kč
    • •
  • 1 292 tis. Kč
    • •
  • MZ
Project

Atherosclerotic changes and DNA adducts (NM10)

Determination of DNA adducts in the thoracic aorta of sudden died men, aged 40 -60 years, as preclinical biomarkers of atherosclerotic changes.......

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 803 tis. Kč
    • •
  • 2 797 tis. Kč
    • •
  • MZ
Project

Globin adducts produced in the metabolism of industrially (NJ4526)

Studies on the formation of specific globin adduct in the metabolism of N, N-dimethylformamide and N-methylformamide in rats and humans with the aim to develop a new biomonitoring method.......

FM - Hygiena

  • 1998 - 1999
    • •
  • 764 tis. Kč
    • •
  • 394 tis. Kč
    • •
  • MZ
Project

New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens (2B08051)

to detect and quantitate specific DNA adducts in urine. Adenine and guanine DNA adducts for their determination in urine. Formation of the DNA adducts derived from 3-nitrobenzanthrone......

CB - Analytická chemie, separace

  • 2008 - 2011
    • •
  • 21 715 tis. Kč
    • •
  • 19 426 tis. Kč
    • •
  • MŠMT
Project

Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs. (NL6058)

: Recognitionof platinum-DNA adducts by human nucleotide excision repair (NER) depends,it is necessary to obtain platinum-DNA adducts that distort the double helix without eliciting of DNA substrates containing a single site-specifi...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • MZ
Project

Hydrolytic cleavage products of protein adducts in urine as a new type of biomarkers in preventive medicine (NV19-09-00378)

Although the adducts with globin have been widely used in preventive medicine as biomarkers of long-term exposures to reactive chemicals, we were the first to explore their subsequent fate in the organism. We found in rats that hydrolytic cl...

Toxicology

  • 2019 - 2022
    • •
  • 7 276 tis. Kč
    • •
  • 6 664 tis. Kč
    • •
  • MZ
Project

Study on mechanism of antineoplastic action of an anticancer drug ellipticine (GA203/06/0329)

remain to be answered; whether adducts generated by ellipticine in healthy tissues are formed also in DNA of target tumor tissues and whether the adduct formation correlatewith pharmacological effects. Another question is whether D...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 190 tis. Kč
    • •
  • 1 190 tis. Kč
    • •
  • GA ČR
Project

Biological monitoring and health risk of occupational exposure to 4,4´- diphenylmethane diisocyanate (NJ7564)

Studies on the relationship between the external exposure to MDI, the levels of the biomarkers (MDA in urine and adducts of MDI with blood proteins), biological responses (symptoms, lung function impairment, bronchial hyperreactivity, antibo...

FM - Hygiena

  • 2003 - 2005
    • •
  • 4 462 tis. Kč
    • •
  • 1 756 tis. Kč
    • •
  • MZ
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