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8 (0,15s) •

Project

Immunohistochemistry of pituitary adenomas (IZ2974)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1995 - 1998
    • •
  • 633 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • MZ
Project

Apolipoprotein E and its in the role colorectal carcinogenesis. (NK6113)

The changes in lipid metabolsim of large intenstine have put in conjuction with the pathogenesis of colorectal carcinoma in recent years.The objective of this project is to prove the relationship between natural polymorphism ApoE and We will analyze ...

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 856 tis. Kč
    • •
  • 856 tis. Kč
    • •
  • MZ
Project

Telomere homeostasis from colorectal adenoma to metastatic cancer. (GA21-27902S)

Altered DNA repair mechanisms and disrupted telomere length homeostasis are prerequisites of cancer initiation. Supposedly, telomere length maintenance changes throughout the cancer continuum. A telomere-driven crisis in precancerous cells with dysfu...

Oncology

  • 2021 - 2024
    • •
  • 12 958 tis. Kč
    • •
  • 12 958 tis. Kč
    • •
  • GA ČR
Project

Development of a New Generation Multiparametric Test for Prediction of Colorectal Neoplasia Recurrence (NV17-31909A)

In years 2017–2020, there will be 200 patients with removed colorectal adenomas >10 mm included. In adenomas high risk areas identified by endoscopist, the histopathology evaluation and molecular examination of intratumoral heterogenity and clonal pr...

FE - Ostatní obory vnitřního lékařství

  • 2017 - 2021
    • •
  • 14 888 tis. Kč
    • •
  • 13 294 tis. Kč
    • •
  • MZ
Project

Identification of diagnostic markers in colorectal cancer by profiling of trascriptome, DNA methylome and microbiome in adenoma-carcinoma transition (NV18-03-00199)

Colorectal cancer (CRC) is the third common cancer worldwide. Since the majority of colorectal carcinomas evolve from adenomatous polyps, identification of these adenomas can reduce CRC mortality. Despite the removal of colonic polyps at an initial c...

General and internal medicine

  • 2018 - 2022
    • •
  • 10 809 tis. Kč
    • •
  • 10 662 tis. Kč
    • •
  • MZ
Project

Endoscopic full thickness resection versus standard therapy of the colorectal neoplasia — prospective randomized study (NV18-08-00246)

Prospective randomized study comparing the effectiveness and safety of the new method of transmural resection (FTR, full thickness resection) and standard therapy (EMR; endoscopic mucosal resection and ESD; endoscopic submucosal dissection) of the co...

General and internal medicine

  • 2018 - 2022
    • •
  • 10 234 tis. Kč
    • •
  • 9 522 tis. Kč
    • •
  • MZ
Project

Internexin-alpha in aggressive/fast- and slow growing clinically non-functioning pituitary adenomas (NV19-01-00435)

Neurosurgical procedure often does not lead to complete removal of non-functioning pituitary macroadenoma (NFPA). However, a persuasive marker for assessing relapse / growth risk of residuum has not yet been discovered. Internexin-alpha (INA) is a ne...

Endocrinology and metabolism (including diabetes, hormones)

  • 2019 - 2022
    • •
  • 8 907 tis. Kč
    • •
  • 8 907 tis. Kč
    • •
  • MZ
Project

Morphological and functional analysis of pituitary adenomas structure prediction and postoperative changes in nasal airflow and olfactory function (NW24-08-00324)

Pituitary adenoma surgery was recently subject to a major transformation due to the advent of endoscopic techniques bringing new challenges in surgical planning and complications management. First section of this project focuses on pituitary adenoma ...

Neurosciences (including psychophysiology)

  • 2024 - 2027
    • •
  • 11 705 tis. Kč
    • •
  • 11 705 tis. Kč
    • •
  • MZ
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