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1 699 (0,108s) •

Project

Identification of diagnostic markers in colorectal cancer by profiling of trascriptome, DNA methylome and microbiome in adenoma-carcinoma transition (NV18-03-00199)

Colorectal cancer (CRC) is the third common cancer worldwide. Since the majority of colorectal carcinomas evolve from adenomatous polyps, identification of these adenomas can reduce CRC mortality. Despite the removal of colonic polyps at an ...

General and internal medicine

  • 2018 - 2022
    • •
  • 10 809 tis. Kč
    • •
  • 10 662 tis. Kč
    • •
  • MZ
Project

Telomere homeostasis from colorectal adenoma to metastatic cancer. (GA21-27902S)

transition may be switched to alternative telomere lengthening (ALT), which enables cells homeostasis in the transition from adenomas to colorectal metastatic cancer with taking......

Oncology

  • 2021 - 2024
    • •
  • 12 958 tis. Kč
    • •
  • 12 958 tis. Kč
    • •
  • GA ČR
Project

Apolipoprotein E and its in the role colorectal carcinogenesis. (NK6113)

The changes in lipid metabolsim of large intenstine have put in conjuction with the pathogenesis of colorectal carcinoma in recent years.The objective of this project is to prove the relationship between natural polymorphism ApoE and We will...

FP - Ostatní lékařské obory

  • 2000 - 2002
    • •
  • 856 tis. Kč
    • •
  • 856 tis. Kč
    • •
  • MZ
Project

Study od epithelial-to-mesenchymal transition associated microRNAs and genes as potential markers for prediction of risk and early detection of metastatic disease in renal cell carcinoma patients (NT13547)

The EMT status reflecting miRNAs identified by expression profiling analysis using Real-Time PCR miRNA Arrays or their target molecules on protein level will enable to identify RCC patients with increased risk of metastatic disease, and by that will ...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 7 431 tis. Kč
    • •
  • 7 431 tis. Kč
    • •
  • MZ
Project

Immunohistochemistry of pituitary adenomas (IZ2974)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1995 - 1998
    • •
  • 633 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • MZ
Project

Quantitative analysis of p16 gene as a potential prognostic marker of bladder transitional cell carcinomas (GP301/01/D142)

for the follow-up of patients with bladder transitional cell carcinomas. We willestablishBladder cancer is the second most frequent malignancy among the tumours of the urinary tract in men - prostate carcinoma being the fi...

FD - Onkologie a hematologie

  • 2001 - 2004
    • •
  • 333 tis. Kč
    • •
  • 333 tis. Kč
    • •
  • GA ČR
Project

Genomic analysis of tumor-associated fibroblasts in head and neck carcinoma The basis for new generation of biologic anti-tumor therapy (NT13488)

umor associated fibroblasts influence biological behavior of cancer stem cells and all malignant clones. One way of their origin is epithelial-mesenchymal transition clone cells and stromal fibroblasts in head and neck carcinoma. In...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 8 759 tis. Kč
    • •
  • 8 759 tis. Kč
    • •
  • MZ
Project

The role of stem cells and factors of epithelial-mesenchymal transition in cancer stromal microenvironment alteration (GAP304/10/1070)

-mesenchymal transition (EMT) or stem cells. The study is aimed to detect stem cells carcinomas comparing benign lesions using indirect immnunohistochemistry on formalin......

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 2 497 tis. Kč
    • •
  • 2 497 tis. Kč
    • •
  • GA ČR
Project

Tumor microenvironment of head and neck carcinoma Prognostic significance of extracellular matrix produced by tumor-associated fibroblasts (NV15-28933A)

demonstrated the important role of human endogenous lectin - galectin-1 on the transition behavior of squamous cell carcinoma of the head and neck. The main effort......

FF - ORL, oftalmologie, stomatologie

  • 2015 - 2018
    • •
  • 11 720 tis. Kč
    • •
  • 11 720 tis. Kč
    • •
  • MZ
Project

Mapping the traits involved in malignant transformation of colorectal adenoma into carcinoma. (GA18-09709S)

Colorectal cancer (CRC) is the third common cancer worldwide. Since the majority of colorectal carcinomas evolve from adenomatous polyps, identification of these adenomas can reduce CRC mortality. Despite the removal of colonic polyps at an ...

Biochemistry and molecular biology

  • 2018 - 2021
    • •
  • 7 488 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
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