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51 (0,078s) •

Project

Roles of extracellular adenosine in hematopoiesis and innate immunity using Drosophila as a model to study these roles in vivo (KJB501410602)

Extracellular adenosine is a potent signaling molecule with various effects in higher organisms. Excessive adenosine is harmful, as in the case of adenosine is the main regulator of adenosine levels in Drosophila, ...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 925 tis. Kč
    • •
  • 1 925 tis. Kč
    • •
  • AV ČR
Project

Physiological roles of adenosine in Drosophila. (KJB501410801)

Adenosine has high impact on physiology by modulating heart function, respiration, sleep, immunity and nervous system. Increased level of adenosine is destructive for both mammals and insects. Growth factors with adenosine ...

ED - Fyziologie

  • 2008 - 2011
    • •
  • 1 176 tis. Kč
    • •
  • 1 176 tis. Kč
    • •
  • AV ČR
Project

Origin of adenosine as a selfish immunity signal (GA17-16406S)

Adenosine emerges as a signaling molecule of important regulatory role. We have shown that when released from immune cells of infected Drosophila, adenosine. Pathways producing adenosine are known but their roles in energy ...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 6 081 tis. Kč
    • •
  • 5 973 tis. Kč
    • •
  • GA ČR
Project

Drosophila model of adenosine deaminase deficiency (GA204/04/1205)

Adenosine deaminase (ADA) is a metabolic enzyme that catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine. It is present by concentration changes of extracellular adenosine/deox...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 785 tis. Kč
    • •
  • 2 785 tis. Kč
    • •
  • GA ČR
Project

The effect of adenosine analogs on hematopoiesis (GA305/02/0423)

elevating extracellular adenosine (dipyridamole + AMP) stimulate proliferation of elucidation of the mechanisms of the receptor action of extracellular adenosine on hematopoiesis. Attention will be focused on testing of selected

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 6 594 tis. Kč
    • •
  • 2 994 tis. Kč
    • •
  • GA ČR
Project

Role of adenosine A3 receptor signaling in regulation of hematopoiesis knowledge obtained from adenosine A3 receptor knock-out mice (GAP303/11/0128)

In earlier studies of the applicants, pharmacologically induced activation of adenosine A3 receptors was found to stimulate murine hematopoiesis. A3 adenosine the role played by adenosine A3 receptors and their agonists in ...

ED - Fyziologie

  • 2011 - 2014
    • •
  • 5 615 tis. Kč
    • •
  • 5 615 tis. Kč
    • •
  • GA ČR
Project

Extracellular adenosine as a stress hormone in Drosophila (GA204/09/1463)

Extracellular adenosine is a very ancient and important signaling molecule years, we have developed a genetic model for extracellular adenosine actions using Drosophila melanogaster and confirmed that flies share many adenosine<...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 497 tis. Kč
    • •
  • 2 497 tis. Kč
    • •
  • GA ČR
Project

RECEPTOR - An agonist of adenosine A3 receptors in therapy of acute radiation diseas (OVBIOFYZ20101)

The project submitted is aimed at supplementing therapeutical approaches targeted at enhancing of regeneration of ionizing radiation-suppressed hematopoietic system with new therapeutical procedures deduced from the research area of adenosine

FP - Ostatní lékařské obory

  • 2010 - 2012
    • •
  • 626 tis. Kč
    • •
  • 313 tis. Kč
    • •
  • MO
Project

Interactions of stable adenosine receptor agonists and granulocyte colony-stimulating factor (G-CSF) in hematopoiesis (GA305/06/0015)

demonstrated that stimulation of adenosine membrane receptors with their agonists modulates on testing the effects of synthetic adenosine analogs, more or less specific for individual subtypes of adenosine receptors, and d...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 157 tis. Kč
    • •
  • 3 157 tis. Kč
    • •
  • GA ČR
Project

The role of signalling through adenosine receptors and its interaction with G-CSF in regulation of haematopoiesis (GP305/03/D050)

of signalling through adenosine receptors in regulation of haematopoiesis, performed. The analysis ofblood serum of mice treated with drugs elevating extracellular adenosine effects of extracellular adenosine, the effects ...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2006
    • •
  • 677 tis. Kč
    • •
  • 677 tis. Kč
    • •
  • GA ČR
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