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1 116 (0,149s) •

Project

Role of adenosine A3 receptor signaling in regulation of hematopoiesis knowledge obtained from adenosine A3 receptor knock-out mice (GAP303/11/0128)

of adenosine A3 receptors was found to stimulate murine hematopoiesis. A3 adenosine receptor knock-out mice will be the principal object of the submitted studies. It may be hypothesized that hematopoiesis in A3ade...

ED - Fyziologie

  • 2011 - 2014
    • •
  • 5 615 tis. Kč
    • •
  • 5 615 tis. Kč
    • •
  • GA ČR
Project

RECEPTOR - An agonist of adenosine A3 receptors in therapy of acute radiation diseas (OVBIOFYZ20101)

system with new therapeutical procedures deduced from the research area of adenosine membrane receptor signaling. Therapeutical effects of the tested drug, an adenosine A3 receptor agonist, IB-MECA, administered a...

FP - Ostatní lékařské obory

  • 2010 - 2012
    • •
  • 626 tis. Kč
    • •
  • 313 tis. Kč
    • •
  • MO
Project

The effect of adenosine analogs on hematopoiesis (GA305/02/0423)

of elucidation of the mechanisms of the receptor action of extracellular adenosine specific for various subtypes of adenosine receptors in experiments in vivo novel, effective pharmacological strategies based on <...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 6 594 tis. Kč
    • •
  • 2 994 tis. Kč
    • •
  • GA ČR
Project

Interactions of stable adenosine receptor agonists and granulocyte colony-stimulating factor (G-CSF) in hematopoiesis (GA305/06/0015)

demonstrated that stimulation of adenosine membrane receptors with their agonists modulates on testing the effects of synthetic adenosine analogs, more or less specific for individual subtypes of adenosine rec...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 3 157 tis. Kč
    • •
  • 3 157 tis. Kč
    • •
  • GA ČR
Project

The influence of adenosine receptors on NK cells mediated antitumor immunity response. (KJB500200614)

an important part of antitumor immune response. NK cells express, besides others, adenosine receptors (ARs), which modulate the production of immune/inflammatory mediators (cytokines,chemokines). These receptors are specif...

EC - Imunologie

  • 2006 - 2008
    • •
  • 845 tis. Kč
    • •
  • 845 tis. Kč
    • •
  • AV ČR
Project

The role of signalling through adenosine receptors and its interaction with G-CSF in regulation of haematopoiesis (GP305/03/D050)

of signalling through adenosine receptors in regulation of haematopoiesis, performed effects of extracellular adenosine, the effects of selective agonist of A1 (CPA) and A3 adenosine receptors (IB-MECA) w...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2006
    • •
  • 677 tis. Kč
    • •
  • 677 tis. Kč
    • •
  • GA ČR
Project

Functions of adenosine signaling in organism (GA14-27816S)

of adenosine receptor deficiency in Drosophila, and to examine evolutionary conservation of adenosine signaling function between Drosophila and vertebrates. Our project includesAdenosine (Ado) is an ubiquitous met...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 6 357 tis. Kč
    • •
  • 6 357 tis. Kč
    • •
  • GA ČR
Project

Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression (GA305/08/0158)

Hitherto performed studies of the applicants of this project have demonstrated the effectiveness of two original experimental pharmacological approaches aimed at stimulation of  regeneration of hematopoiesis supressed by exposure of  a mammalian orga...

FD - Onkologie a hematologie

  • 2008 - 2012
    • •
  • 5 001 tis. Kč
    • •
  • 5 001 tis. Kč
    • •
  • GA ČR
Project

Drosophila model of adenosine deaminase deficiency (GA204/04/1205)

, transport, the genes for adenosine receptors etc. are well conserved among animals. WeAdenosine deaminase (ADA) is a metabolic enzyme that catalyzes the irreversible deamination of adenosine and deoxyadenosine to...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 785 tis. Kč
    • •
  • 2 785 tis. Kč
    • •
  • GA ČR
Project

Immunomodulatory activity of adenosine receptor systém and its role in immunobiological effects of antiviral acyclic nucleoside phosphonates (GA305/03/1470)

of adenosine and cAMP in virus diseases remain to be firmly established. Only little is known about the impact of activation of adenosine receptors on secretionThe project is focused on the interference of adenosine

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 3 395 tis. Kč
    • •
  • 3 395 tis. Kč
    • •
  • GA ČR
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