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Projects

10 projects (1,733s) •

Project

Molecular mechanisms of Trichomonas vaginalis infection role of energy metabolism (GC13-09208J)

changes in energy metabolism and the composition of surface adhesins during of hydrogenosomal enzymes that have been suggested to serve as adhesins.......

EE - Mikrobiologie, virologie

  • 2013 - 2015
    • •
  • 6 716 tis. Kč
    • •
  • 6 716 tis. Kč
    • •
  • GA ČR
Project

Probing specific interactions of well-defined glycosaminoglycans with European Lyme disease borrelia adhesins at atomic resolution (GC23-06525J)

We will characterize the specific interactions of synthetic glycosaminoglycans (GAGs) with decorin binding proteins (Dbps) from Borrelia causing Lyme disease. These proteins play a role in the dissemination and virulence of the bacterium in the host....

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 231 tis. Kč
    • •
  • 9 231 tis. Kč
    • •
  • GA ČR
Project

Role of adhesins in formation of Borrelia burgdorferi biofilm-like structures (8J19AT009)

Confirm or reject a relation between DbpA/BBK32 expression and biofilm formation in B. burgdorferi. Resolve cellular architecture of B. burgdorferi biofilm-like structures using cryo-scanning electron microscopy. Resolve topographical features with...

Microbiology

  • 2019 - 2021
    • •
  • 118 tis. Kč
    • •
  • 118 tis. Kč
    • •
  • MŠMT
Project

Insuline resistance and secretion, substrate metabolism and markers of atherosclerotic damage in polycystic ovary syndrome - therapeutic modulation. (NB6696)

Object of the study is to compare the influence of transdermal and oral route of estrogen application in combination with steroid antiandrogen on insulin resistance, secretion, substrate metabolism and markers of early atherosclerotic damage in PCOS....

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 886 tis. Kč
    • •
  • 2 431 tis. Kč
    • •
  • MZ
Project

Structure-function studies on lectins and adhesins from microbial patogens (GA303/06/0570)

Oligosaccharide-mediated recognition and adhesion are key points in the early steps of infection of many pathogens. The project is focused mainly to structure-function studies of carbohydrate-binding proteins from Pseudomonas aeruginosa and Burkholde...

CE - Biochemie

  • 2006 - 2008
    • •
  • 2 176 tis. Kč
    • •
  • 2 176 tis. Kč
    • •
  • GA ČR
Project

Biological activity of the Neisseria meningitidis RTX protein FrpC (GA310/06/0720)

Neisseria meningitidis, the agent of invasive meningococcal disease, produces a family of FrpC-like RTX proteins of unknown role in meningococcal lifestyle. We have recently shown that FrpC can bind a variety of host cell types and undergoes a unique...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 4 901 tis. Kč
    • •
  • 4 901 tis. Kč
    • •
  • GA ČR
Project

Study of proteins from pathogens involved in host organism recognition (GA13-25401S)

. The project is focused on lectins and adhesins from bacterial pathogens and airborne...

CE - Biochemie

  • 2013 - 2017
    • •
  • 8 986 tis. Kč
    • •
  • 8 986 tis. Kč
    • •
  • GA ČR
Project

Structural and bio-nanomechanical view at bacterial dissemination in the host (GF22-18647K)

adhesins DbpA/B and BBK32 significantly enhance the borrelial motility...

Microbiology

  • 2022 - 2025
    • •
  • 8 115 tis. Kč
    • •
  • 8 115 tis. Kč
    • •
  • GA ČR
Project

Development of unique vaccines against serious diseases of animals (TH01010837)

1. Development of unique polyvalent vaccines for immunization sows and cows before farrowing against enteric diseases of their offspring. A wide range of antigens contained in the vaccine permits to induce an effective protection through one or two a...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2015 - 2016
    • •
  • 23 258 tis. Kč
    • •
  • 12 450 tis. Kč
    • •
  • TA ČR
Project

Role of filamentous hemagglutinin in complement resistance of B. pertussis (GA24-10936S)

The Gram-negative respiratory pathogen Bordetella pertussis produces a surface-exposed adhesin called filamentous hemagglutinin (FhaB) that participates in B. pertussis attachment to airway epithelium. FhaB was also proposed to exert an immu...

Infectious Diseases

  • 2024 - 2026
    • •
  • 12 462 tis. Kč
    • •
  • 12 462 tis. Kč
    • •
  • GA ČR
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