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5 780 (0,607s) •

Project

Preparation of polyclonal cancer-specific T-cells for adoptive cellular immunotherapy of prostate cancer (NV16-28135A)

deaths in men in Europe and the United States. The T-cell-based adoptive cellular project proposes a development of a protocol for T-cell-based ACI of PCa. Our ACI will use ex vivo generated autologous

EC - Imunologie

  • 2016 - 2019
    • •
  • 10 666 tis. Kč
    • •
  • 10 666 tis. Kč
    • •
  • MZ
Project

Adoptive transfer of CMV specific CD8+ T-cells to treat CMV infection after transplantation (GA13-22777S)

and their administration as adoptive immunotherapy. During the years 2007-2010, CMV reactivation after treatment. In the absence of CMV-specific T-cells in patients with CMV reactivation, we on the safety of admin...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 5 588 tis. Kč
    • •
  • 5 588 tis. Kč
    • •
  • GA ČR
Project

Genetically downregulated expression of the immune checkpoint inhibitor LAIR-1 in tumor-specific T cells as a novel strategy for breaking the resistance of solid tumors to adoptive T cell (NU23-08-00071)

patients with solid tumors still do not benefit from this therapy. Adoptive T cell in the treatment of solid tumors. The failure is often caused by an inability of T cells expressed on T cell...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2023 - 2026
    • •
  • 11 244 tis. Kč
    • •
  • 11 244 tis. Kč
    • •
  • MZ
Project

Immunotherapy Using Different Tumor Antigens in The Treatment of Multiple Myeloma (NR8945)

for future clinical study with adoptive immunotherapy using dendritic cells or specificThe aim of this project is to find an optimal strategy of T cell stimulation using dendritic cells loaded wi...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 6 929 tis. Kč
    • •
  • 6 587 tis. Kč
    • •
  • MZ
Project

Safer biotechnology of the allogeneic hematopoietic stem cells in solid and hematological cancer as an adoptive immunotherapy (2B06058)

The aim of the proposed project is an improvement of adoptive immunotherapy using an experimental allogeneic hematopoietic stem cell transplantation. It is focused on pre-clinical research in safer biotechnology of allogene...

EC - Imunologie

  • 2006 - 2011
    • •
  • 76 750 tis. Kč
    • •
  • 67 796 tis. Kč
    • •
  • MŠMT
Project

Evaluation of Cellular Immunity and Molecular Analysis of Myeloma-Specific T cells in Patients with Multiple Myeloma (NC7475)

The aim of this study is to identify and characterize myeloma-specific T cells in patients with multiple myeloma. Immunocompetent cells will be evaluated before, during and after immunotherapy in patients with mult...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 2 498 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
Project

Development of methods for cellular and gene therapy of hematological malignancies. (NV15-34498A)

. This novel treatment method is based on the use adoptively transferred T lymphocytes. Next, we propose to develop methods for selective expansion of T cells specificSignificant progress in the field of tumor ...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 14 055 tis. Kč
    • •
  • 14 055 tis. Kč
    • •
  • MZ
Project

Natural Killer cell based adoptive cellular immunotherapy of hemato-oncology disorders. (NU22-08-00287)

The use of natural killer (NK) cells as a cellular immunotherapy has increased cell adoptive therapy is a promising cancer therapeutic approach as well as clinical-scale method to produce NK cells for ...

Immunology

  • 2022 - 2025
    • •
  • 10 115 tis. Kč
    • •
  • 10 115 tis. Kč
    • •
  • MZ
Project

Analysis of T cells specific for BK polyomavirus and Adenovirus in haploidentical transplant recipients with hemorrhagic cystitis (NV17-31593A)

of protocols for expansion of T cells for immunotherapy of opportunistic viral infections effector T cells in HC patients with BK or AdV infection will result in determination of protective levels of anti...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 8 503 tis. Kč
    • •
  • 7 606 tis. Kč
    • •
  • MZ
Project

Distinct roles of IL-2 for antigen-primed CD8+ and CD4+ T cells a paradigm shift in T cell biology and implication for cancer immunotherapy (GA25-16348S)

+ and CD4+ T cells. This project aims to change the current paradigm in the field cells. Our objective is to prove that IL-2 is vital for activated CD8+ T cells and CD8+ T cell mediated i...

Immunology

  • 2025 - 2027
    • •
  • 8 997 tis. Kč
    • •
  • 8 997 tis. Kč
    • •
  • GA ČR
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