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103 (0,083s) •

Project

Novel therapeutic approaches in narcolepsy (GA17-08596S)

orexin receptor agonists could be valuable for its treatment. Indications that treatment of narcolepsy with orexin agonists would be effective came from a study, development of small-molecule orexin agonists, able to penet...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2021
    • •
  • 7 564 tis. Kč
    • •
  • 7 300 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors (GA305/09/0681)

binding site among subtypes classical agonists display poor selectivity. Ectopic agonists like xanomeline or AC-42, however, represent a new class of drugs that bind, oligomerization and conformational changes induced by ectopic an...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 6 959 tis. Kč
    • •
  • 6 959 tis. Kč
    • •
  • GA ČR
Project

Perspective application of xenosensor nuclear receptors ligands in therapy of cholestatic liver diseases (GA22-05167S)

) receptors are important regulators of detoxification. In the past, agonists of PXR) the effects of the prototype mouse Car agonist TCPOBOP and novel mouse inverse agonists) if prototype Car agonist TCPOBOP has a ...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 12 904 tis. Kč
    • •
  • 12 856 tis. Kč
    • •
  • GA ČR
Project

Analysis of signalling bias of novel synthetic muscarinic agonists (GJ19-06106Y)

development of affinity-based subtype-specific agonists is extremely difficult. An alternative approach to the development of selective agonists is to exploit signalling muscarinic subtypes of muscarinic agonists of new ch...

Pharmacology and pharmacy

  • 2019 - 2022
    • •
  • 4 246 tis. Kč
    • •
  • 4 246 tis. Kč
    • •
  • GA ČR
Project

Glucagon-like peptide 1 agonists and sodium-glucose cotransporter 2 inhibitors as a new pharmacological tool for the prevention of end-organ damage (NW25-01-00076)

receptor agonists (GLP-1 agonists). The renoprotective effects may be related project, the possible renoprotective effects of GLP-1 agonist or its combination of the mechanism of the renoprotective effects of GLP-1 ago...

Endocrinology and metabolism (including diabetes, hormones)

  • 2025 - 2028
    • •
  • 11 213 tis. Kč
    • •
  • 11 213 tis. Kč
    • •
  • MZ
Project

Polymer vaccines novel high potent immunostimulants for infectious disseases treatment (GJ16-14957Y)

of the immunostimulatory agents, so called adjuvants. Toll-like receptor (TLR) agonists, expressed, direct application of free TLR-agonists is limited by their relatively high toxicity, an antigen and the TLR-agonists. Suc...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 4 624 tis. Kč
    • •
  • 4 624 tis. Kč
    • •
  • GA ČR
Project

Cardiovascular effects of incretin therapy in type 2 diabetes mellitus (NT13046)

The aim of the project is to identify the mechanisms of cardioprotective effects of GLP-1 agonists. Two GLP-1 agonists (exenatide and liraglutide-1 agonists. In total, 90 patients with T2DM will be included. The patients GL...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2012 - 2015
    • •
  • 8 127 tis. Kč
    • •
  • 8 127 tis. Kč
    • •
  • MZ
Project

Serotonergic Mechanisms of Anxiety Pharmacological Studies in Agonistic Behaviour (IA70852)

9G - 9

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

Research of anxiolytic activity of alpha2 adrenergic agonists (GP305/05/P003)

successful and apart from buspirone no other agonist of this receptor has been introduced and alpha-2 agonists change animal behavior in anxiety tests. The aim of the......

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 784 tis. Kč
    • •
  • 784 tis. Kč
    • •
  • GA ČR
Project

Influence of Toll-like Receptor Agonists on Immunogenicity of Tumour Cells in B cell Chronic Lymphocytic Leukemia (GP310/08/P353)

and initiate host defence. Some of their agonists allow improvement of their antigen-presentation functions. In this project we will study effect of known agonists of Toll-like) and functional impact on T cell activation after trea...

EC - Imunologie

  • 2008 - 2010
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 103