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97 (0,126s) •

Project

Alkyl chloroformate-induced derivatization in sample preparation and analysis of compounds of biomedical and biological importance (GA203/01/1586)

Capability of alkyl chloroformates (RCF) to esterify carboxylic groups in aqueous media immediately, discovered by the applicant a decade ago, opened new possibilities in sample pretreatment and rapid analysis of compounds of biomed...

CB - Analytická chemie, separace

  • 2001 - 2003
    • •
  • 4 504 tis. Kč
    • •
  • 1 517 tis. Kč
    • •
  • GA ČR
Project

New alkyl chloroformate labeling strategies for the targeted and comparative mass spectrometry-based metabolomics (GA13-18509S)

The goal of the proposed project is to investigate new strategies of metabolite labeling with alkyl chloroformates that possess stable isotopes in their structures after a simple sample treatment with the chloroformate reag...

CB - Analytická chemie, separace

  • 2013 - 2016
    • •
  • 5 145 tis. Kč
    • •
  • 5 145 tis. Kč
    • •
  • GA ČR
Project

New perspectives in determination of body fluid amino acids and peptides for diagnostic purposes (NB6708)

Rapid profiling of important body fluid biomarkers for diagnostic purposes make possible procedures based on sample/compound pretreatment with alkyl chloroformates in aqueous media and employment of chromatography (GC, HPLC).......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 2 331 tis. Kč
    • •
  • 1 870 tis. Kč
    • •
  • MZ
Project

New approaches in body fluid metabolic profiling and their usage in clinical diagnostics. (NS9755)

Profiling of body fluid acidic metabolites via rapid phase-transfer derivatization of the species with chloroformates straightly in the fluid will be methodically innovated by two unique procedures: one is combining the compound fluoroalkyl ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 3 739 tis. Kč
    • •
  • 2 752 tis. Kč
    • •
  • MZ
Project

New methods for metabolomic analysis of hardly determined metabolites (GA17-22276S)

with fluoroalkyl chloroformates in conjunction with the novel GC-APCI-MS technology.(2) The new 13C-alkyl chloroformate based labeling strategy for the identification of protic functional groups, unknown species and the s...

CB - Analytická chemie, separace

  • 2017 - 2021
    • •
  • 6 804 tis. Kč
    • •
  • 6 285 tis. Kč
    • •
  • GA ČR
Project

Design and synthesis of novel haloformates as advanced reagents in diagnostics and screening compounds of biological importance (GA203/04/0192)

Polar compounds possesing protic functional groups including the carboxyl ones proved to be smoothly converted into organophilic species upon treating with alkyl chloroformates in both aqueous and non-aqueous media. The novel approa...

CB - Analytická chemie, separace

  • 2004 - 2006
    • •
  • 1 499 tis. Kč
    • •
  • 1 499 tis. Kč
    • •
  • GA ČR
Project

Nontargeted and targeted metabolite profiling in urine of patients with breast or prostate cancer diagnosis (GAP206/10/2401)

. The discovery of capability of fluoroalkyl chloroformates to block immediately aliphatic...

CB - Analytická chemie, separace

  • 2010 - 2014
    • •
  • 3 358 tis. Kč
    • •
  • 3 358 tis. Kč
    • •
  • GA ČR
Project

MULTICOMPLEX DIAGNOSTICS OF B-VITAMIN BIOMARKERS AND NUTRITIONAL STATUS IN PLASMA MICROSAMPLES USING A SIMPLE SAMPLE PRETREATMENT (GA303/06/1674)

direct extractive alkylation of markers in body fluids with new perfluoroalkylated chloroformates and their chromatographic-mass spectrometric determination. The......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2007
    • •
  • 948 tis. Kč
    • •
  • 948 tis. Kč
    • •
  • GA ČR
Project

New approaches to alkylchloroformate-mediated sample preparation for parallel GC-MS and LC-MS for metabolite analysis in biofluids (GA203/09/2014)

on intelligent sample preparation methods prior to instrumental analysis. Alkyl chloroformate...

CB - Analytická chemie, separace

  • 2009 - 2011
    • •
  • 2 087 tis. Kč
    • •
  • 2 087 tis. Kč
    • •
  • GA ČR
Project

Molecular dosimetry of the exposure to alkylating agents. Determination of the adducts with globin using modified Edman degradation procedure. (NJ7387)

Specific analytical procedures for determination of alkyl adducts of alkylating agents with N-terminal valine of globin will be implemented and validated. Purpose: Improvement of biological monitoring of exposure to industrial toxic...

FM - Hygiena

  • 2003 - 2005
    • •
  • 2 995 tis. Kč
    • •
  • 1 292 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 97