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3 034 (0,091s) •

Project

DNA damage tolerance by plants (ME 535)

alkylation da, mage is rather tolerated than repaired. We propose to study activity of a key enzyme - Pol theta in regard to presence of alkylation damage in DNASequence analysis of Arabidopsis genome revealed sev...

EB - Genetika a molekulární biologie

  • 2002 - 2003
    • •
  • 1 405 tis. Kč
    • •
  • 355 tis. Kč
    • •
  • MŠMT
Project

N7 Substituted guanines for early diagnostics of DNA damage; development of synthetic and analytical methods (GA203/06/0888)

obtained will be used as authentic standards in the diagnostics of the DNA damage. 7-Hydroxyalkylguanines and 7-hydroxyalkenylguanines, DNA adducts derived from alkenes and alkadienesElectrophilic xenobiotics are capable o...

CC - Organická chemie

  • 2006 - 2008
    • •
  • 1 403 tis. Kč
    • •
  • 1 403 tis. Kč
    • •
  • GA ČR
Project

The determination of expression levels of DNA repair and cell cycle genes in peripheral blood lymphocytes in styrene exposed individuals. (IAA500390806)

(pathways repairing styrene alkylation and oxidative DNA damage)., expression levels in DNA repair (XRCC1, XPC) and cell cycle genes (p53, p21, bax, bcl2 between the base excision repair phenotypes and expression ...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 2 509 tis. Kč
    • •
  • 2 509 tis. Kč
    • •
  • AV ČR
Project

Monitoring DNA damage in model plants and agronomic crops exposed to environmental mutagens and agricultural chemicals (GA521/99/0532)

and agronomiccrop plants. The main objectives are to (i)Calibrate the induction of DNA damage the single cell gel electrophoresis assay for detecting DNA damage in leaves acting mutagens such as alkyl alk...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 2 521 tis. Kč
    • •
  • 1 654 tis. Kč
    • •
  • GA ČR
Project

Inhibition of cell response to DNA damage for the treatment of glioblastoma multiforme (NW24J-03-00005)

generates DNA damage including single or double strand breaks that are repaired by several cellular mechanisms orchestrated by DNA damage response kinases. There are three key cellular orchestrators for DNA

Oncology

  • 2024 - 2027
    • •
  • 6 788 tis. Kč
    • •
  • 6 788 tis. Kč
    • •
  • MZ
Project

DNA-repair genes transfer to hematopoietic cells for protection against toxic and mutagenic effects of alkylating antitumor agents. (IZ3557)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 3 160 tis. Kč
    • •
  • 3 160 tis. Kč
    • •
  • MZ
Project

Analysis of functional alterations of mutant forms of p53 protein in human cancers. (NC7131)

-regulete the expression of CD95 after DNA damaging treatments, and whether increasedThe analysis of effects of alkylating drugs, topoisomerase and mitotic inhibitors, DNA intercalators, antimetabolites and radiati...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 7 615 tis. Kč
    • •
  • 7 568 tis. Kč
    • •
  • MZ
Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

damage. Monitoring of DNA-damaging pollutants in the environment, together with analysis of damage to cellular DNA, belong to important steps in prevention of serious) in detection of DNA dam...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Development of electrochemical biodetectors for DNA damage (IAA4004108)

electrochemical biodetector (biosensor) for DNA damage (both in vitro and in cells) and DNA damaging agents. A procedure developed in our laboratory which allows to detect DNA detection of DNA cl...

CG - Elektrochemie

  • 2001 - 2003
    • •
  • 1 758 tis. Kč
    • •
  • 804 tis. Kč
    • •
  • AV ČR
Project

Radiation damage to DNA protein complexes (1P05OC085)

assessment of partner bond and their damage in specific complex DNA-protein after irradiation by ionisating radiation...

BO - Biofyzika

  • 2005 - 2007
    • •
  • 2 320 tis. Kč
    • •
  • 981 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 3 034