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7 (0,078s) •

Project

Cellular and molecular mechanisms of pain transmission at spinal cord level. (GA305/06/1115)

Pathological pain is often characterised by states of increased sensitivity to innocuous and noxious stimuli (allodynia and hyperalgesia). The therapy of these painful states is difficult as the underlying physiological mechanisms are not fu...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 2 969 tis. Kč
    • •
  • 2 969 tis. Kč
    • •
  • GA ČR
Project

The role of spinal inhibitory neurons in the development of painful states. (GA20-19136S)

Chronic and neuropathic pain conditions are often characterized by attacks of spontaneous pain and allodynia. The treatments available are not effective and accompanied by serious side effects. In order to develop new effective analgesic tre...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 6 209 tis. Kč
    • •
  • 6 209 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular mechanisms of pain transmission at spinal cord level. (GA305/09/1228)

Pathological pain states characterized by pain to innocuous stimuli (allodynia), hyperlagesia and spontaneous chronic pain often become debilitating diseases recalcitrant to the best treatment efforts, as the cellular and physiological mecha...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 5 060 tis. Kč
    • •
  • 5 060 tis. Kč
    • •
  • GA ČR
Project

Molecular Basis of Thermosensitive TRP Ion Channel Regulation in Nociceptive Neurons (GA19-03777S)

of thermal allodynia with the aim to clarify the putative role of specific TRP channels...

Neurosciences (including psychophysiology)

  • 2019 - 2021
    • •
  • 6 364 tis. Kč
    • •
  • 6 046 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular mechanisms of nociception at spinal cord level. (GA309/03/0752)

Spinothalamic tract (STT) is considered to be one of the major ascending pathways involved in the transmission of acute and chronic pain. Sensitization of STT neurons is thought to be one of the important mechanisms underlying changes in pain percept...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 2 074 tis. Kč
    • •
  • 2 074 tis. Kč
    • •
  • GA ČR
Project

CELLULAR AND MOLECULAR MECHANISMS OF PAIN TRANSMISSION AT SPINAL CORD LEVEL. (GA15-11138S)

Acute pain is an important physiological mechanism that helps to protect organism against damage. Chronic pain is a debilitating disease often characterized by spontaneous pain and by pain induced by innocuous (allodynia) and noxious (hypera...

FH - Neurologie, neurochirurgie, neurovědy

  • 2015 - 2017
    • •
  • 4 725 tis. Kč
    • •
  • 4 725 tis. Kč
    • •
  • GA ČR
Project

Activation and regulation mechanisms of nociceptor-specific transient receptor potential channels physiological role in acute and chronic pain (GA305/09/0081)

allodynia. We hope that this study will provide a new perspective on how the ?nociceptor...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2013
    • •
  • 6 559 tis. Kč
    • •
  • 6 559 tis. Kč
    • •
  • GA ČR
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