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261 (0,078s) •

Project

Structural and functional determinants on TRPM5 and TRPM8 channels (IAA600110701)

in the lower part of alpha helix of TM6 in gating processes of TRPM5 and TRPM8 will be also...

ED - Fyziologie

  • 2007 - 2011
    • •
  • 3 072 tis. Kč
    • •
  • 3 072 tis. Kč
    • •
  • AV ČR
Project

Protein Affinity and Selectivity to Cellular Membranes (GA20-20152S)

Spatial and temporal organisation of proteins in cell is a crucial aspect for understanding the complex machinery of living cells. Peripheral proteins are organised at membranes of specific organelles to perform specialized functions. However, the re...

Physical chemistry

  • 2020 - 2022
    • •
  • 8 105 tis. Kč
    • •
  • 8 105 tis. Kč
    • •
  • GA ČR
Project

Conformational Equilibria in Nucleic Acids and Force Field Development (GA17-16107S)

, such as BI/BII equilibrium of B-DNA, ZI/ZII equilibrium of Z-DNA, alpha/gamma substates complex equilibria in conformational transitions, helix end fraying etc. Unfortunately......

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2021
    • •
  • 2 563 tis. Kč
    • •
  • 2 485 tis. Kč
    • •
  • GA ČR
Project

Structural and functional determinants on channels TRPC3, TRPV1, TRPV2 and TRPA1 (GA303/07/0915)

, and to describe the role of the of aminoacids residues in the lower part of alpha- helix...

CE - Biochemie

  • 2007 - 2009
    • •
  • 3 165 tis. Kč
    • •
  • 3 165 tis. Kč
    • •
  • GA ČR
Project

Cold-shock proteins of streptomycetes and their role in regulation of gene expression (GA203/98/0422)

of proteins, mRNA and tRNA to ribosome. Helix-destabilizing activity of the induced and inRNAase stimulated band shift assay. Protein(s) with helix-destabilizing activity......

CE - Biochemie

  • 1998 - 2000
    • •
  • 1 525 tis. Kč
    • •
  • 1 525 tis. Kč
    • •
  • GA ČR
Project

Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs. (NL6058)

on their ability to destabilize DNA double-helix. To achieve biological and clinical efficacy,it is necessary to obtain platinum-DNA adducts that distort the double helix without eliciting......

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 2 180 tis. Kč
    • •
  • 2 180 tis. Kč
    • •
  • MZ
Project

Metrology for emerging targeted alpha therapies (9B23008)

The overall objective of the project is to address the unique and unmet metrological challenges of targeted alpha therapies....

Nuclear physics

  • 2023 - 2026
    • •
  • 11 873 tis. Kč
    • •
  • 5 937 tis. Kč
    • •
  • MŠMT
Project

Carbohydrate biotechnology network for grain legumes (CABINET) (OK 283)

=B13oligosaccharides; alpha-galactosides; legumes; peas; food preparation; nutritionImprovement of the nutritional value of grain legumes by changing the content of alpha-galactosides. Determination of the alpha-galactoside...

GM - Potravinářství

  • 1997 - 1999
    • •
  • 667 tis. Kč
    • •
  • 545 tis. Kč
    • •
  • MŠMT
Project

Properties of α-D- and α-L-Oligodeoxynucleotides with Isopolar Phosphonate Internucleotide Linkages (GA17-12703S)

antisense compounds based on structurally diverse phosphonate alpha-D- and alpha-L and architecture of hybrid duplexes of novel alpha-D and alpha-L-oligodeoxynucleotides. The outcome of the project should be new e...

CC - Organická chemie

  • 2017 - 2021
    • •
  • 7 824 tis. Kč
    • •
  • 5 325 tis. Kč
    • •
  • GA ČR
Project

Smart Akcelerátor+ I in the South Bohemia (EH22_010/0002822)

helix on a regional, interregional and international scale; increasing the knowledge the triple/quadruple helix. The project will also contribute to strengthening......

Social sciences, interdisciplinary

  • 2023 - 2026
    • •
  • 57 171 tis. Kč
    • •
  • 11 407 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 261