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7 (0,138s) •

Project

Study of the mechanism and development of drug abuse, and participation of stress (NF6627)

Drug abuse for amphetamine and cocaine with participation of sress will be studied on models using inbred rats. Behavioral (cognitive functions) and biochemical studies (cAMP, nitric oxide, diaphorase, stress hormones) will be performed para...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 3 339 tis. Kč
    • •
  • 3 339 tis. Kč
    • •
  • MZ
Project

Central and peripheral pathways underlying feeding-related effects of cocaine and amphetamine regulated transcript (CART) peptides (GA303/05/0614)

CART (cocaine and amphetamine regulated transcript) peptides are relatively novel peptide neurotransmitters involved in feeding and satiety, stress, endocrine regulation and other physiological processes. The grant proposal aims at elucidati...

CE - Biochemie

  • 2005 - 2007
    • •
  • 2 873 tis. Kč
    • •
  • 2 459 tis. Kč
    • •
  • GA ČR
Project

Study of metabolism of synthetic psychedelic amines as new toxic agents in clinical and forensic toxicology (NR8332)

The biotransformation of selected illegal synthetic drugs will be studied using toxicological methods based on GC-MS. After administration of toxic agents to experimental rats, excreted urine will be collected, and structure of metabolites determined...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 1 431 tis. Kč
    • •
  • 1 431 tis. Kč
    • •
  • MZ
Project

Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats (NS10509)

The aim of the planned project is to determine the effect of prenatal methamphetamine (MA) exposure on drug-seeking behavior in adulthood. The following drugs will be tested: (1) the same drug as prenatally (MA); (2) the related drugs (amphetamin...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 3 151 tis. Kč
    • •
  • 3 151 tis. Kč
    • •
  • MZ
Project

Objective diagnosis of intoxication by a new designer drugs (NT13593)

The main principle of the grant project lies in the development of sophisticated analytical methods allowing identification and to determine the designer drug. The project is aimed at a group of synthetic canabinoids and a group of synthetic derivati...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2014
    • •
  • 5 441 tis. Kč
    • •
  • 5 441 tis. Kč
    • •
  • MZ
Project

New pharmacological interventions influencing energy homeostasis and development of insulin resistance/ type 2 diabetes mellitus (GAP303/10/1368)

Recently discovered brain-born and brain acting neuropeptides attenuating food intake such as prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transcript (CART) peptide represent new possibilities in development of f...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
    • •
  • 9 715 tis. Kč
    • •
  • 9 715 tis. Kč
    • •
  • GA ČR
Project

Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats? (GA305/09/0126)

(amphetamine, cocaine, MDMA); 3) unrelated drugs (morphine, cannabinoids). The effect...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2013
    • •
  • 5 487 tis. Kč
    • •
  • 5 487 tis. Kč
    • •
  • GA ČR
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