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52 (0,176s) •

Project

Effects of beta-amyloid on the function of cholinergic synapses. (NF5183)

Beta-amyloid plays a key role in the pathogeny of Alzheimer`s disease. Recent observations indicate that beta-amyloid has direct negative effects on the synthesis and release of acetylcholine on cholinergic synapses, but the mechani...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 4 808 tis. Kč
    • •
  • 3 103 tis. Kč
    • •
  • MZ
Project

Interactions of intracellular amyloid beta and diagnosis of Alzheimer disease (NV16-27611A)

(complexes of amyloid beta peptides and some intracellular proteins) in cerebrospinal) and to detect complexes of oligomeric amyloid or of amyloid beta 1-42 with intracellular with the current biomarkers (amyloid ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
    • •
  • 12 342 tis. Kč
    • •
  • 12 342 tis. Kč
    • •
  • MZ
Project

New strategy for inhibition of amyloid fibril formation (GJ18-06255Y)

of Parkinson’s disease. This soluble protein aggregates into amyloid fibrils via amyloid fibril formation are very restricted. They are based on the molecules amyloid fibrils. Such approaches are not efficient for developm...

Biophysics

  • 2018 - 2021
    • •
  • 5 695 tis. Kč
    • •
  • 5 695 tis. Kč
    • •
  • GA ČR
Project

THE RELATION OF MORPHOLOGY OF PULMONARY VEINS TO ATRIAL FIBRILLATION, WITH PARTICULAR ATTENTION TO ISOLATED ATRIAL AMYLOID (NA7592)

" will be histologically examined for the presence, quantity, and character of isolated atrial amyloid - one of the "senile" amyloids. A hypothesis is put forward that amyloidosis......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 1 933 tis. Kč
    • •
  • 1 911 tis. Kč
    • •
  • MZ
Project

Evaluation of cellular toxicity of nanoparticles and protein amyloid fibrils. (LH12014)

The main objective of the project is to gain original data about the cellular toxicity of nanoparticles and amyloid fibrils and to publish the data in impacted scientific journals. Another objective of the project is to further the contacts ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 3 060 tis. Kč
    • •
  • 2 768 tis. Kč
    • •
  • MŠMT
Project

Investigation on the role of cholinergic neurotransmission in aging and pathogenesis of Alzheimer´s disease (IAA500110703)

pathogenesis is increased production of beta-amyloid. Noxious species of beta-amyloid are solubleoligomers that appear much earlier than the characteristic amyloid plaques. Involvement accumulating beta-amyloid. W...

ED - Fyziologie

  • 2007 - 2011
    • •
  • 7 060 tis. Kč
    • •
  • 7 060 tis. Kč
    • •
  • AV ČR
Project

Diagnosis of Alzheimer disease based on detections of complexes of amyloid beta peptide and of some endogenous substances in cerebrospinal fluid (NT11225)

After developments of new highly sensitive methods (via ELISA and surface plasmon resonance biosensors) , we will evaluate the levels of two complexes of amyloid beta peptides with either mitochondrial enzyme 17beta-hydroxysteroid people. Th...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 9 657 tis. Kč
    • •
  • 9 657 tis. Kč
    • •
  • MZ
Project

Myopathies in the elderly over 80 with hip fracture (NG6419)

80-90 in patients over 80 with hip fracture are to be invelved.Muscle bippsy in time of surgery is to be get and investigatedy on atrophy and myopathy icluding IBM. We will use electronmicroscopy as well as antibodies against beta amyloid,be...

FE - Ostatní obory vnitřního lékařství

  • 2000 - 2002
    • •
  • 647 tis. Kč
    • •
  • 647 tis. Kč
    • •
  • MZ
Project

Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40 (GA305/09/0457)

Although causes of Alzheimer disease are not known yet in a detail, it is suggested that amyloid beta peptides play a key role in the pathogenesis of disease on the research od drugs that via binding to amyloid beta peptides can eli...

CE - Biochemie

  • 2009 - 2011
    • •
  • 2 238 tis. Kč
    • •
  • 2 238 tis. Kč
    • •
  • GA ČR
Project

Search of mechanisms responsible for adverse effects of amyloid beta on muscarinic receptor transmission. (GA14-05696S)

signaling preceding amyloid deposition. It was not due to changes in muscarinic by beta-amyloid. Knowledge of molecular mechanisms and time-course is of prime......

ED - Fyziologie

  • 2014 - 2016
    • •
  • 4 497 tis. Kč
    • •
  • 4 497 tis. Kč
    • •
  • GA ČR
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