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619 (0,088s) •

Project

Targeted damage of the DNA repair mechanisms as a tool for cancer therapy (NV15-31604A)

diverse unnatural nucleotide units (nucleoside analogs and/or phosphonate types the whole pathway from the design and synthesis of nucleoside, nucleotide, and oligonucleotide analogues, through the analys...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 17 562 tis. Kč
    • •
  • 17 562 tis. Kč
    • •
  • MZ
Project

The impact of cytidine metabolic pathways on cytarabine therapy of hematological malignancies and new diagnostic tools for their analysis (NU22-08-00148)

), deoxycytidine kinase (dCK), 5'-nucleotidase and human equilibrative nucleoside transporter (hENT1) participate in the regulation of cellular nucleotide and nucleoside pools and also in the metabolism of therapeutically s...

Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

  • 2022 - 2025
    • •
  • 10 318 tis. Kč
    • •
  • 10 318 tis. Kč
    • •
  • MZ
Project

Novel antivirals and antineoplastics (1QS400550501)

on nucleoside, nucleotide and nucleobase structure, to determine their transport) purine nucleosides with potential cytostatic or anti-RNA viral activity; (4, alkene or alkyne units with cytostatic potential and (5) carboc...

CC - Organická chemie

  • 2005 - 2009
    • •
  • 20 500 tis. Kč
    • •
  • 20 500 tis. Kč
    • •
  • AV ČR
Project

New Antivirals and Antineoplastics (1M0508)

and HBV mutants, poxviruses and RNA viruses.To study new analogs of acyclic nucleosand cytostatic effects of conformationally rigid cyclohexane nucleoside analogues, C-substituted purines with functionalized C-substituents, their <...

CC - Organická chemie

  • 2005 - 2011
    • •
  • 316 074 tis. Kč
    • •
  • 268 113 tis. Kč
    • •
  • MŠMT
Project

Modified nucleosides, nucleotides and oligonucleotides and their application in biomedicine (TA03010598)

Modified nucleosides, nucleotides and oligonucleotides are intensively used in medicine mainly as drugs or as components of diagnostic kits. The project is focused on the development of new tools for the detection of proliferating c...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 15 280 tis. Kč
    • •
  • 9 880 tis. Kč
    • •
  • TA ČR
Project

New purine nucleoside analogues for therapeutic applications (OC D13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

CC - Organická chemie

  • 2001 - 2003
    • •
  • 2 662 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • MŠMT
Project

New purine nucleoside analogues for therapeutic applications (1P04OCD13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 891 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

Preparation of Peptidomimetic Prodrugs of Acyclic Nucleoside Phosphonates as Antivirals with Improved Bioavailability (ME10040)

Transformation of acyclic nucleoside phosphonates (ANPs) to appropriate prodrugs helps to improve their low bioavailability connected with a limited transport through the cell membrane caused by a presence of negative charges in the molecule...

CC - Organická chemie

  • 2010 - 2012
    • •
  • 2 400 tis. Kč
    • •
  • 2 400 tis. Kč
    • •
  • MŠMT
Project

Novel types of acyclic nucleoside phosphonates with potential antimalarial activity hypoxanthine-guanine-xanthine phosphoribosyltransferase inhibitors (GAP207/11/0108)

Recently, some acyclic nucleoside phosphonates (ANPs) were recognized as in vitro inhibitors of the key enzyme of purine salvage pathway hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT). The malarial parasite Plasmodium falci...

CC - Organická chemie

  • 2011 - 2014
    • •
  • 7 432 tis. Kč
    • •
  • 7 432 tis. Kč
    • •
  • GA ČR
Project

Platinum-linked nucleotides as virus inhibitors (OC D8.40)

or its analogues are combined with various derivatives of nucleosides and nucleotides cisplatin or its analogues are combined with various derivatives of nucleosides and nucleotides so that during the transport of...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 7 960 tis. Kč
    • •
  • 1 180 tis. Kč
    • •
  • MŠMT
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